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A110141-250mg

250mg

In stock

$28.90

A110141-1g

In stock

$94.90

A110141-5g

Available within 4-8 weeks(?)

$427.90

Basic Description

Synonyms	Fluoresceinamine, isomer 1 \| Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-amino-3',6'-dihydroxy- \| fluorescein-5-amine \| EX-A1779 \| Fluoresceinamine isomer 1 \| SCHEMBL220211 \| 5-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one \|
Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	Fluorescence marker. Selectively targets malignant glioma tissue in vivo when covalently linked to human serum albumin at a molar ratio of 1:1without bleaching nor penetrating into surrounding brain edema or necrotic tissue. Blood-brain barrier permeable.
Storage Temp	Argon charged
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Fluoresceinamine, isomer I is a building block for synthesis of fluorescein. A reagent for fluorescence studies

Names and Identifiers

IUPAC Name	6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
INCHI	InChI=1S/C20H13NO5/c21-10-1-4-14-13(7-10)19(24)26-20(14)15-5-2-11(22)8-17(15)25-18-9-12(23)3-6-16(18)20/h1-9,22-23H,21H2
InChi Key	GZAJOEGTZDUSKS-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C=C1N)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
Isomeric SMILES	C1=CC2=C(C=C1N)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
WGK Germany	3
PubChem CID	76845
Molecular Weight	347.32
Beilstein	48395
Reaxy-Rn	48395

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
B2325307	Certificate of Analysis	May 30, 2022	A110141
G2216112	Certificate of Analysis	May 30, 2022	A110141
G2216122	Certificate of Analysis	May 30, 2022	A110141
B2325306	Certificate of Analysis	May 27, 2021	A110141
C2210084	Certificate of Analysis	May 27, 2021	A110141

Chemical and Physical Properties

Solubility	Soluble in water (partly), methanol (10 mg/ml), and acetone.
Sensitivity	Hygroscopic,Heat & light sensitive.
Melt Point(°C)	223℃

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P337+P313:IF eye irritation persists: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P301+P312+P330:IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
WGK Germany	3
Reaxy-Rn	48395

FAQs and Articles

FAQ

Fluorescent Probes - Absorption and Fluorescence

Categories: Technical articles

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Fluorescence Fuorescent Probe Fluorescent dyes

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yang Yimeng, Chao Danming. (2020) Electrochromic and Electrofluorochromic Performance of Novel Polysiloxane bearing Tetraaniline and Fluorescein Groups. International Journal of Electrochemical Science, 15 (9245). [PMID:] [10.20964/2020.09.40]
2. Qian Li, Jing Yang, Wenzhan Yu, Liqiong He, Renlong Zhou, Changming Nie, Lifu Liao, Xilin Xiao. (2023) Two Fe(III)/Eu(III) Salophen complex-based optical sensors for determination of organophosphorus pesticide monocrotophos. Analytical Methods, 15 (19): (2334-2342). [PMID:37140268] [10.1039/D3AY00255A]
3. Huitong Luo, Zetao Wang, Zhichao He, Zemin Ling, Hao Wang, Jiayi Zhu, Jingjun Nie, Dafu Chen, Qi Feng, Xiaodong Cao. (2023) Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation. Biomaterials Science, 11 (10): (3629-3644). [PMID:37010367] [10.1039/D3BM00359K]
4. Xin Liu, Fan Wang, Li Liu, Tiantian Li, Xiangyu Zhong, Hongsheng Lin, Yi Zhang, Wei Xue. (2023) Functionalized polydopamine nanospheres as in situ spray for photothermal image-guided tumor precise surgical resection. BIOSENSORS & BIOELECTRONICS, 222 (114995). [PMID:36516631] [10.1016/j.bios.2022.114995]
5. Hua Pan, Weilan Huang, Litao Wu, Qihao Hong, Zhongxuan Hu, Meijing Wang, Fang Zhang. (2022) A pH Dual-Responsive Multifunctional Nanoparticle Based on Mesoporous Silica with Metal-Polymethacrylic Acid Gatekeeper for Improving Plant Protection and Nutrition. Nanomaterials, 12 (4): (687). [PMID:35215015] [10.3390/nano12040687]
6. Liu Yipeng, Li Bingyan, Zhang Huixia, Liu Yong, Xie Ping. (2022) Detection of Microcystin-LR in the Cells and Natural Lake Water Samples by A Unique Fluorescence-Based Method. JOURNAL OF FLUORESCENCE, 32 (2): (505-519). [PMID:34981282] [10.1007/s10895-021-02882-2]
7. Dongxu Lan, Yulian Shang, Hongxian Su, Minhua Liang, Yang Liu, Haofei Li, Qi Feng, Xiaodong Cao, Hua Dong. (2021) Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary. ACS Biomaterials Science & Engineering, 7 (10): (4971–4981). [PMID:34503336] [10.1021/acsbiomaterials.1c00980]
8. Qidi Zhang, Ming Zou, Wanyu Wang, Jinyan Li, Xiao Liang. (2021) Design, Synthesis, and Characterization of Tracers and Development of a Fluorescence Polarization Immunoassay for Rapid Screening of 4,4′-Dinitrocarbanilide in Chicken Muscle. Foods, 10 (8): (1822). [PMID:34441602] [10.3390/foods10081822]
9. Peifei Wang, Songbai Liu. (2020) Development of a Gemini Interfacial Antioxidant for Oil in Water Emulsion with Gallic Acid and Dodecyl Gemini Chains. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (37): (9953–9960). [PMID:32816466] [10.1021/acs.jafc.0c00807]
10. Aiyun Liu, Huaisong Wang, Xiaoshuang Hou, Yu Ma, Gongjun Yang, Yanglong Hou, Ya Ding. (2020) Combinatory antitumor therapy by cascade targeting of a single drug. Acta Pharmaceutica Sinica B, 10 (667). [PMID:32322469] [10.1016/j.apsb.2019.08.011]
11. Shanshan Wang, Shanshan Wu, Songbai Liu. (2019) Integration of (+)-catechin and β-sitosterol to achieve excellent radical-scavenging activity in emulsions. FOOD CHEMISTRY, 272 (596). [PMID:30309587] [10.1016/j.foodchem.2018.08.098]
12. Qiuju Li, Anan Sun, Yinsong Si, Min Chen, Limin Wu. (2017) One-Pot Synthesis of Polysaccharide–Diphenylalanine Ensemble with Gold Nanoparticles and Dye for Highly Efficient Detection of Glutathione. CHEMISTRY OF MATERIALS, 29 (16): (6758–6765). [PMID:] [10.1021/acs.chemmater.7b01649]
13. Wei Xu, Ran Guan, Fushan Shi, Aifang Du, Songhua Hu. (2017) Structural analysis and immunomodulatory effect of polysaccharide from Atractylodis macrocephalae Koidz. on bovine lymphocytes. CARBOHYDRATE POLYMERS, 174 (1213). [PMID:28821047] [10.1016/j.carbpol.2017.07.041]
14. Hongying Su, Qingming Jia, Shaoyun Shan. (2016) Synthesis and characterization of Schiff base contained dextran microgels in water-in-oil inverse microemulsion. CARBOHYDRATE POLYMERS, 152 (156). [PMID:27516260] [10.1016/j.carbpol.2016.06.091]
15. Yan Yang, Yingjie Lei, Xinrong Zhang, Sichun Zhang. (2016) A ratiometric strategy to detect hydrogen sulfide with a gold nanoclusters based fluorescent probe. TALANTA, 154 (190). [PMID:27154665] [10.1016/j.talanta.2016.03.066]
16. Yuxiu Xing , Jun Peng , Kai Xu, Weihong Lin , Shuxi Gao , Yuanyuan Ren , Xuefeng Gui , Shengyuan Liang , Mingcai Chen. (2016) Polymerizable Molecular Silsesquioxane Cage Armored Hybrid Microcapsules with In Situ Shell Functionalization. CHEMISTRY-A EUROPEAN JOURNAL, 22 (6): (2114-2126). [PMID:26749019] [10.1002/chem.201504473]
17. Wenhua Li, Yurong Cai, Qiwei Zhong, Ying Yang, Subhas C. Kundu, Juming Yao. (2015) Silk sericin microcapsules with hydroxyapatite shells: protection and modification of organic microcapsules by biomimetic mineralization. Journal of Materials Chemistry B, 4 (2): (340-347). [PMID:32263376] [10.1039/C5TB02328A]
18. Xingwang Zhang, Tianpeng Zhang, Yanghuan Ye, Huaqing Chen, Hua Sun, Xiaotong Zhou, Zhiguo Ma, Baojian Wu. (2015) Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 94 (30). [PMID:25936860] [10.1016/j.ejpb.2015.04.023]
19. Yuliang Xiao, Pingli Li, Yanna Cheng, Xinke Zhang, Juzheng Sheng, Decai Wang, Juan Li, Qian Zhang, Chuanqing Zhong, Rui Cao, Fengshan Wang. (2014) Enhancing the intestinal absorption of low molecular weight chondroitin sulfate by conjugation with α-linolenic acid and the transport mechanism of the conjugates. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 465 (143). [PMID:24524826] [10.1016/j.ijpharm.2014.02.009]

References

1. Yang Yimeng, Chao Danming. (2020) Electrochromic and Electrofluorochromic Performance of Novel Polysiloxane bearing Tetraaniline and Fluorescein Groups. International Journal of Electrochemical Science, 15 (9245). [PMID:] [10.20964/2020.09.40]
2. Qian Li, Jing Yang, Wenzhan Yu, Liqiong He, Renlong Zhou, Changming Nie, Lifu Liao, Xilin Xiao. (2023) Two Fe(III)/Eu(III) Salophen complex-based optical sensors for determination of organophosphorus pesticide monocrotophos. Analytical Methods, 15 (19): (2334-2342). [PMID:37140268] [10.1039/D3AY00255A]
3. Huitong Luo, Zetao Wang, Zhichao He, Zemin Ling, Hao Wang, Jiayi Zhu, Jingjun Nie, Dafu Chen, Qi Feng, Xiaodong Cao. (2023) Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation. Biomaterials Science, 11 (10): (3629-3644). [PMID:37010367] [10.1039/D3BM00359K]
4. Xin Liu, Fan Wang, Li Liu, Tiantian Li, Xiangyu Zhong, Hongsheng Lin, Yi Zhang, Wei Xue. (2023) Functionalized polydopamine nanospheres as in situ spray for photothermal image-guided tumor precise surgical resection. BIOSENSORS & BIOELECTRONICS, 222 (114995). [PMID:36516631] [10.1016/j.bios.2022.114995]
5. Hua Pan, Weilan Huang, Litao Wu, Qihao Hong, Zhongxuan Hu, Meijing Wang, Fang Zhang. (2022) A pH Dual-Responsive Multifunctional Nanoparticle Based on Mesoporous Silica with Metal-Polymethacrylic Acid Gatekeeper for Improving Plant Protection and Nutrition. Nanomaterials, 12 (4): (687). [PMID:35215015] [10.3390/nano12040687]
6. Liu Yipeng, Li Bingyan, Zhang Huixia, Liu Yong, Xie Ping. (2022) Detection of Microcystin-LR in the Cells and Natural Lake Water Samples by A Unique Fluorescence-Based Method. JOURNAL OF FLUORESCENCE, 32 (2): (505-519). [PMID:34981282] [10.1007/s10895-021-02882-2]
7. Dongxu Lan, Yulian Shang, Hongxian Su, Minhua Liang, Yang Liu, Haofei Li, Qi Feng, Xiaodong Cao, Hua Dong. (2021) Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary. ACS Biomaterials Science & Engineering, 7 (10): (4971–4981). [PMID:34503336] [10.1021/acsbiomaterials.1c00980]
8. Qidi Zhang, Ming Zou, Wanyu Wang, Jinyan Li, Xiao Liang. (2021) Design, Synthesis, and Characterization of Tracers and Development of a Fluorescence Polarization Immunoassay for Rapid Screening of 4,4′-Dinitrocarbanilide in Chicken Muscle. Foods, 10 (8): (1822). [PMID:34441602] [10.3390/foods10081822]
9. Peifei Wang, Songbai Liu. (2020) Development of a Gemini Interfacial Antioxidant for Oil in Water Emulsion with Gallic Acid and Dodecyl Gemini Chains. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (37): (9953–9960). [PMID:32816466] [10.1021/acs.jafc.0c00807]
10. Aiyun Liu, Huaisong Wang, Xiaoshuang Hou, Yu Ma, Gongjun Yang, Yanglong Hou, Ya Ding. (2020) Combinatory antitumor therapy by cascade targeting of a single drug. Acta Pharmaceutica Sinica B, 10 (667). [PMID:32322469] [10.1016/j.apsb.2019.08.011]
11. Shanshan Wang, Shanshan Wu, Songbai Liu. (2019) Integration of (+)-catechin and β-sitosterol to achieve excellent radical-scavenging activity in emulsions. FOOD CHEMISTRY, 272 (596). [PMID:30309587] [10.1016/j.foodchem.2018.08.098]
12. Qiuju Li, Anan Sun, Yinsong Si, Min Chen, Limin Wu. (2017) One-Pot Synthesis of Polysaccharide–Diphenylalanine Ensemble with Gold Nanoparticles and Dye for Highly Efficient Detection of Glutathione. CHEMISTRY OF MATERIALS, 29 (16): (6758–6765). [PMID:] [10.1021/acs.chemmater.7b01649]
13. Wei Xu, Ran Guan, Fushan Shi, Aifang Du, Songhua Hu. (2017) Structural analysis and immunomodulatory effect of polysaccharide from Atractylodis macrocephalae Koidz. on bovine lymphocytes. CARBOHYDRATE POLYMERS, 174 (1213). [PMID:28821047] [10.1016/j.carbpol.2017.07.041]
14. Hongying Su, Qingming Jia, Shaoyun Shan. (2016) Synthesis and characterization of Schiff base contained dextran microgels in water-in-oil inverse microemulsion. CARBOHYDRATE POLYMERS, 152 (156). [PMID:27516260] [10.1016/j.carbpol.2016.06.091]
15. Yan Yang, Yingjie Lei, Xinrong Zhang, Sichun Zhang. (2016) A ratiometric strategy to detect hydrogen sulfide with a gold nanoclusters based fluorescent probe. TALANTA, 154 (190). [PMID:27154665] [10.1016/j.talanta.2016.03.066]
16. Yuxiu Xing , Jun Peng , Kai Xu, Weihong Lin , Shuxi Gao , Yuanyuan Ren , Xuefeng Gui , Shengyuan Liang , Mingcai Chen. (2016) Polymerizable Molecular Silsesquioxane Cage Armored Hybrid Microcapsules with In Situ Shell Functionalization. CHEMISTRY-A EUROPEAN JOURNAL, 22 (6): (2114-2126). [PMID:26749019] [10.1002/chem.201504473]
17. Wenhua Li, Yurong Cai, Qiwei Zhong, Ying Yang, Subhas C. Kundu, Juming Yao. (2015) Silk sericin microcapsules with hydroxyapatite shells: protection and modification of organic microcapsules by biomimetic mineralization. Journal of Materials Chemistry B, 4 (2): (340-347). [PMID:32263376] [10.1039/C5TB02328A]
18. Xingwang Zhang, Tianpeng Zhang, Yanghuan Ye, Huaqing Chen, Hua Sun, Xiaotong Zhou, Zhiguo Ma, Baojian Wu. (2015) Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 94 (30). [PMID:25936860] [10.1016/j.ejpb.2015.04.023]
19. Yuliang Xiao, Pingli Li, Yanna Cheng, Xinke Zhang, Juzheng Sheng, Decai Wang, Juan Li, Qian Zhang, Chuanqing Zhong, Rui Cao, Fengshan Wang. (2014) Enhancing the intestinal absorption of low molecular weight chondroitin sulfate by conjugation with α-linolenic acid and the transport mechanism of the conjugates. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 465 (143). [PMID:24524826] [10.1016/j.ijpharm.2014.02.009]

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5-Aminofluorescein - 96%, high purity , CAS No.3326-34-9