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5-Azacytidine - 98%, high purity , DNA (cytosine-5)-methyltransferase 1 inhibitor, CAS No.320-67-2, DNA (cytosine-5)-methyltransferase 1 inhibitor

  • ≥98%
Item Number
A100625
Grouped product items
SKUSizeAvailabilityPrice Qty
A100625-50mg
50mg
In stock
$9.90
A100625-250mg
250mg
In stock
$18.90
A100625-1g
1g
In stock
$58.90
A100625-5g
5g
In stock
$229.90
A100625-25g
25g
In stock
$1,034.90

Potent DNMT1 inhibitor. Induces DNA hypomethylation.

Basic Description

Synonyms5-azacytidine|Azacitidine|320-67-2|Ladakamycin|Azacytidine|Vidaza|Mylosar|5-azacitidine|Azacitidina|Azacitidinum|Azacitidinum [INN-Latin]|5-AZAC|Azacitidina [INN-Spanish]|Antibiotic U 18496|C8H12N4O5|Onureg|NSC-102816|U-18496|CCRIS 60|4-Amino-1-beta-D-rib
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionDNA (cytosine-5)-methyltransferase 1 inhibitor

Product Properties

ALogP-2.2

Associated Targets

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488180979
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180979
IUPAC Name 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
INCHI InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
InChi Key NMUSYJAQQFHJEW-KVTDHHQDSA-N
Canonical SMILES C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
Isomeric SMILES C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
WGK Germany 3
RTECS XZ3017500
PubChem CID 9444
Molecular Weight 244.2
Beilstein 620461
Reaxy-Rn 620461

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

17 results found

Lot NumberCertificate TypeDateItem
F2302726Certificate of AnalysisJan 10, 2023 A100625
F2302721Certificate of AnalysisJan 10, 2023 A100625
F2302720Certificate of AnalysisJan 10, 2023 A100625
F2302719Certificate of AnalysisJan 10, 2023 A100625
F2302718Certificate of AnalysisJan 10, 2023 A100625
F2302717Certificate of AnalysisJan 10, 2023 A100625
F2302716Certificate of AnalysisJan 10, 2023 A100625
F2302714Certificate of AnalysisJan 10, 2023 A100625
K1812067Certificate of AnalysisSep 15, 2022 A100625
F1828085Certificate of AnalysisApr 27, 2022 A100625
C2218077Certificate of AnalysisJan 24, 2022 A100625
C2218075Certificate of AnalysisJan 24, 2022 A100625
C2218073Certificate of AnalysisJan 24, 2022 A100625
C2218072Certificate of AnalysisJan 24, 2022 A100625
B2219237Certificate of AnalysisJan 15, 2022 A100625
B2219236Certificate of AnalysisJan 15, 2022 A100625
B2219233Certificate of AnalysisJan 15, 2022 A100625

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Chemical and Physical Properties

SolubilitySoluble in water
Sensitivityheat & light sensitive
Melt Point(°C)228-230°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H302:Harmful if swallowed

H340:May cause genetic defects

H350:May cause cancer

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P201:Obtain special instructions before use.

P308+P313:IF exposed or concerned: Get medical advice/attention.

P281:Use personal protective equipment as required.

P403:Store in a well-ventilated place.

P270:Do not eat, drink or smoke when using this product.

P202:Do not handle until all safety precautions have been read and understood.

P330:Rinse mouth.

P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

WGK Germany 3
RTECS XZ3017500
Reaxy-Rn 620461
Merck Index 887

Related Documents

References

1. Stresemann C, Lyko F.  (2008)  Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine..  Int J Cancer,  123  (1): (8-13).  [PMID:18425818]
2. Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast Jr RC.  (2011)  Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy..  Cancer,  117  (19): (4424-38).  [PMID:21491416]
3. Dear AE.  (2016)  Epigenetic Modulators and the New Immunotherapies..  N Engl J Med,  374  (7): (684-6).  [PMID:26886527]
4. Jones PA, Taylor SM.  (1980)  Cellular differentiation, cytidine analogs and DNA methylation..  Cell,  20  (1): (85-93).  [PMID:6156004]
5. Chen J et al..  (2019)  5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis..  Cancer Manag Res,  11  (9517-9528).  [PMID:31807076]
6. Schwenzer H et al..  (2021)  LARP1 isoform expression in human cancer cell lines..  RNA Biol,  18  (2): (237-247).  [PMID:32286153]
7. Fort RS et al..  (2018)  Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth..  BMC Cancer,  18  (127).  [PMID:29394925]
8. Nam H et al..  (2022)  Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα..  Nat Commun,  13  (1972).  [PMID:35418126]
9. Alarcón MA et al..  (2020)  The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer..  Int J Mol Sci,  21  (24):   [PMID:33322837]
10. Jacobs AH.  (1977)  The skin in childhood..  Hosp Pract,  12  (8): (91-112).  [PMID:142744]

Solution Calculators