Determine the necessary mass, volume, or concentration for preparing a solution.
Basic Description
| Specifications & Purity | γ-irradiated, BioReagent, suitable for hybridoma, lyophilized powder |
|---|---|
| Biochemical and Physiological Mechanisms | 5-Azacytidine is a deoxycytidine analog and a demethylating agent. It acts as a potential antineoplastic agent for acute myelogenous leukemia. 5-Azacytidine activates repressed genes by inhibiting DNA methylation. 5-Azacytidine also affects protein synthe |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Grade | BioReagent, suitable for hybridoma, γ-irradiated |
| Product Description | Chemical structure: nucleoside Application:5-Azacytidine may be used to induce in vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. It may also be used to study the effects of 5-Azacytidine on the immune regulatory myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). Used to study the effects of the DNA incorporated molecule on DNA methylation processes. |
Product Properties
| ALogP | -2.2 |
|---|
Names and Identifiers
| IUPAC Name | 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one |
|---|---|
| INCHI | InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 |
| InChi Key | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
| Canonical SMILES | C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N |
| Isomeric SMILES | C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N |
| WGK Germany | 3 |
| RTECS | XZ3017500 |
| PubChem CID | 9444 |
| Molecular Weight | 244.2 |
| Beilstein | 620461 |
| Reaxy-Rn | 620461 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Solubility | acetic acid: water (1:1): 5 mg/mL, clear, colorless |
|---|---|
| Melt Point(°C) | 228-230°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H302:Harmful if swallowed H340:May cause genetic defects H350:May cause cancer |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. P281:Use personal protective equipment as required. P403:Store in a well-ventilated place. P270:Do not eat, drink or smoke when using this product. P202:Do not handle until all safety precautions have been read and understood. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
| WGK Germany | 3 |
| RTECS | XZ3017500 |
| Reaxy-Rn | 620461 |
| Merck Index | 887 |