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CAMK:Calcium/calmodulin-dependent protein kinases
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine , CAS No.C608731, Inhibitor of microtubule affinity regulating kinase 3;Inhibitor of microtubule affinity regulating kinase 4

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5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine , CAS No.C608731, Inhibitor of microtubule affinity regulating kinase 3;Inhibitor of microtubule affinity regulating kinase 4

Moligand™

PubChem CID: 145900918

Item Number

C608731

Grouped product items
SKU	Size	Availability	Price	Qty
C608731-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608731-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

microtubule affinity regulating kinase 3 Inhibitor microtubule affinity regulating kinase 4 Inhibitor

Basic Description

Synonyms	compound 14
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of microtubule affinity regulating kinase 3;Inhibitor of microtubule affinity regulating kinase 4

Associated Targets

STK17A Tchem Serine/threonine-protein kinase 17A 0 Activities

Discover Target: STK17A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBK1 Tchem Serine/threonine-protein kinase TBK1 0 Activities

Discover Target: TBK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK3 Tchem MAP/microtubule affinity-regulating kinase 3 0 Activities

Discover Target: MARK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 0 Activities

Discover Target: MARK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NUAK1 Tchem NUAK family SNF1-like kinase 1 0 Activities

Discover Target: NUAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K9 Tchem Mitogen-activated protein kinase kinase kinase 9 0 Activities

Discover Target: MAP3K9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK1 Tchem Serine/threonine-protein kinase MARK1 0 Activities

Discover Target: MARK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
INCHI	InChI=1S/C23H29N7O/c1-2-17(15-30-8-10-31-11-9-30)12-19(3-1)28-23-26-14-21(18-4-5-18)22(29-23)25-7-6-20-13-24-16-27-20/h1-3,12-14,16,18H,4-11,15H2,(H,24,27)(H2,25,26,28,29)
InChi Key	HZHDCONQUBRRDH-UHFFFAOYSA-N
Canonical SMILES	C(Cc1c[nH]cn1)Nc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1
Isomeric SMILES	C1CC1C2=CN=C(N=C2NCCC3=CN=CN3)NC4=CC=CC(=C4)CN5CCOCC5
PubChem CID	145900918

Database links

PubChem CID	145900918

Certificates

Certificate of Analysis(COA)

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References

1. Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, Mathea S, Axtman AD. (2022) Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.. J Med Chem, 65 (2): (1313-1328). [PMID:34333981]

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