5-Hexynoic Acid-NHS Ester contains a propargyl group and an NHS ester group. This reagent is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
1.He Ji-Xiang, Fei Zheng-Cong, Fu Ling, Tian Cai-Ping, He Fu-Chu, Chi Hao, Yang Jing. (2022) A modification-centric assessment tool for the performance of chemoproteomic probes. Nature Chemical Biology, 18 (8):(904-912). [PMID:35864333]
References
1.He Ji-Xiang, Fei Zheng-Cong, Fu Ling, Tian Cai-Ping, He Fu-Chu, Chi Hao, Yang Jing. (2022) A modification-centric assessment tool for the performance of chemoproteomic probes. Nature Chemical Biology, 18 (8):(904-912). [PMID:35864333]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.