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5-Hydroxyflavone - >98.0%(HPLC), high purity , CAS No.491-78-1

  • ≥98%(HPLC)
Item Number
H157353
Grouped product items
SKUSizeAvailabilityPrice Qty
H157353-50mg
50mg
In stock
$98.90
H157353-100mg
100mg
In stock
$157.90
H157353-250mg
250mg
In stock
$355.90
H157353-500mg
500mg
In stock
$639.90
H157353-1g
1g
In stock
$1,151.90
H157353-5g
5g
In stock
$5,183.90

Basic Description

Synonyms5-Hydroxyflavone|491-78-1|Primuletin|5-hydroxy-2-phenylchromen-4-one|5-hydroxy-2-phenyl-4H-chromen-4-one|NSC-26745|5-Hydroxy-2-phenylchromone|5-Hydroxy-2-phenyl-4-benzopyrone|5-Hydroxy-2-phenyl-chromen-4-one|CHEMBL16807|MLS002639146|378AE9MHL3|NSC26745|4H
Specifications & Purity≥98%(HPLC)
Shipped InNormal
Note500mg卖完停产,不再备货

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1B1 Tchem Cytochrome P450 1B1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FBP1 Tchem Fructose-1,6-bisphosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TOP2A Tclin DNA topoisomerase 2-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PKM Tchem Pyruvate kinase PKM 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1A1 Tchem Cytochrome P450 1A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B10 Tchem Aldo-keto reductase family 1 member B10 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GNAS Tbio Protein ALEX 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TARDBP Tchem TAR DNA-binding protein 43 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NTRK2 Tclin BDNF/NT-3 growth factors receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NEU2 Tbio Sialidase-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488184085
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184085
IUPAC Name 5-hydroxy-2-phenylchromen-4-one
INCHI InChI=1S/C15H10O3/c16-11-7-4-8-13-15(11)12(17)9-14(18-13)10-5-2-1-3-6-10/h1-9,16H
InChi Key IYBLVRRCNVHZQJ-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(C=CC=C3O2)O
Isomeric SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(C=CC=C3O2)O
WGK Germany 3
PubChem CID 68112
Molecular Weight 238.24
Beilstein 18(5)2,254
Reaxy-Rn 194429

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot NumberCertificate TypeDateItem
B2209255Certificate of AnalysisDec 20, 2021 H157353
B2209257Certificate of AnalysisDec 20, 2021 H157353
B2209258Certificate of AnalysisDec 20, 2021 H157353
B2209259Certificate of AnalysisDec 20, 2021 H157353
B2209261Certificate of AnalysisDec 20, 2021 H157353
B2209264Certificate of AnalysisDec 20, 2021 H157353

Chemical and Physical Properties

Melt Point(°C)157-161℃

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3
Reaxy-Rn 194429

Related Documents

References

1. A R Ibrahim,Y J Abul-Hajj.  (1989-12-01)  Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus..  Applied and environmental microbiology,  55  ((12)): (3140-3142).  [PMID:2619306]
2. M Vietri,A Pietrabissa,R Spisni,F Mosca,G M Pacifici.  (2002-08-07)  7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate..  Xenobiotica; the fate of foreign compounds in biological systems,  32  ((7)): (563-571).  [PMID:12162852]
3. Errol G Lewars,Raymond E March.  (2007-04-28)  Fragmentation of 3-hydroxyflavone; a computational and mass spectrometric study..  Rapid communications in mass spectrometry : RCM,  21  ((10)): (1669-1679).  [PMID:17465009]
4. R Sai Sathish,A Goutam Raju,G Nageswara Rao,C Janardhana.  (2007-05-29)  A fluorescent fluoride ion probe based on a self-organized ensemble of 5-hydroxyflavone-Al(III) complex..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  69  ((1)): (282-285).  [PMID:17531527]
5. Wimal Herath,Julie Rakel Mikell,Amber Lynn Hale,Daneel Ferreira,Ikhlas Ahmad Khan.  (2008-04-02)  Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones..  Chemical & pharmaceutical bulletin,  56  ((4)): (418-422).  [PMID:18379084]
6. Sankarlal Ash,Sankar Prasad De,Santanu Pyne,Ajay Misra.  (2009-09-18)  Excited state intramolecular proton transfer in 3-hydroxy flavone and 5-hydroxy flavone: a DFT based comparative study..  Journal of molecular modeling,  16  ((5)): (831-839).  [PMID:19760438]
7. Juan José Baeza-Baeza,María Celia García-Álvarez-Coque.  (2014-06-20)  Some insights on the description of gradient elution in reversed-phase liquid chromatography..  Journal of separation science,  37  ((17)): (2269-2277).  [PMID:24945785]
8. David J Sukovich,Cyrus Modavi,Markus de Raad,Robin N Prince,J Christopher Anderson.  (2015-01-27)  DNA-Linked Enzyme-Coupled Assay for Probing Glucosyltransferase Specificity..  ACS synthetic biology,  ((7)): (833-841).  [PMID:25621860]
9. Ricardo Q Aucelio,Juliana M Carvalho,Juliana T Real,Luis Maqueira-Espinosa,Aurora Pérez-Gramatges,Andrea R da Silva.  (2016-04-24)  Study of the interaction of flavonoids with 3-mercaptopropionic acid modified CdTe quantum dots mediated by cetyltrimethyl ammonium bromide in aqueous medium..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  172  (147-155).  [PMID:27106812]
10. Ester Peris-García,Jorge Rodríguez-Martínez,Juan J Baeza-Baeza,María.  (2018-06-21)  Search of non-ionic surfactants suitable for micellar liquid chromatography..  Analytical and bioanalytical chemistry,  410  ((20)): (5043-5057).  [PMID:29922861]
11. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263).  [PMID:30174044]
12. Jie Bai,Shengyu Zhao,Xiaoqing Fan,Yonghui Chen,Xiaowen Zou,Minwan Hu,Baolian Wang,Jing Jin,Xiaojian Wang,Jinping Hu,Dan Zhang,Yan Li.  (2019-02-23)  Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships..  Toxicology and applied pharmacology,  369  (49-59).  [PMID:30790579]
13. Richard Lantz,Brian Busbee,Ewa P Wojcikiewicz,Deguo Du.  (2020-05-28)  Flavonoids with Vicinal Hydroxyl Groups Inhibit Human Calcitonin Amyloid Formation..  Chemistry (Weinheim an der Bergstrasse, Germany),  26  ((57)): (13063-13071).  [PMID:32458489]
14. C Lapouge,J P Cornard.  (2006-07-13)  Time dependent density functional theory study of electronic absorption properties of lead(II) complexes with a series of hydroxyflavones..  The journal of physical chemistry. A,  109  ((30)): (6752-6761).  [PMID:16834029]
15. Yajing Fang,Mengmeng Xia,Fuqiang Liang,Weiwei Cao,Siyi Pan,Xiaoyun Xu.  (2019-01-29)  Establishment and Use of Human Mouth Epidermal Carcinoma (KB) Cells Overexpressing P-Glycoprotein To Characterize Structure Requirements for Flavonoids Transported by the Efflux Transporter..  Journal of agricultural and food chemistry,  67  ((8)): (2350-2360).  [PMID:30688455]
16. Bogusław Buszewski,Petar Žuvela,Gulyaim Sagandykova,Justyna Walczak-Skierska,Paweł Pomastowski,Jonathan David,Ming Wah Wong.  (2020-03-21)  Mechanistic Chromatographic Column Characterization for the Analysis of Flavonoids Using Quantitative Structure-Retention Relationships Based on Density Functional Theory..  International journal of molecular sciences,  21  ((6)):   [PMID:32192096]
17. Stanislav Sukhikh,Svetlana Noskova,Svetlana Ivanova,Liubov Skrypnik,Artem Pungin,Elena Ulrikh,Evgeny Chupakhin,Olga Babich.  (2021-07-03)  Study of the Properties of In Vitro Dactylorhiza maculata (L.) Soó (Family Orchidaceae) Extracts..  Plants (Basel, Switzerland),  10  ((7)):   [PMID:34209935]

Solution Calculators