5-LOX inhibitor 2m , CAS No.L607227, Inhibitor of 5-LOX

Item Number

L607227

Grouped product items
SKU	Size	Availability	Price	Qty
L607227-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
L607227-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of 5-LOX

Names and Identifiers

IUPAC Name	(2-(diphenylamino)-4-(4-methoxyphenyl)thiazol-5-yl)(phenyl)methanone
INCHI	InChI=1S/C29H22N2O2S/c1-33-25-19-17-21(18-20-25)26-28(27(32)22-11-5-2-6-12-22)34-29(30-26)31(23-13-7-3-8-14-23)24-15-9-4-10-16-24/h2-20H,1H3
InChi Key	GCBYJNQEZBSRJO-UHFFFAOYSA-N
Canonical SMILES	COc1ccc(cc1)c1nc(sc1C(=O)c1ccccc1)N(c1ccccc1)c1ccccc1
Isomeric SMILES	COC1=CC=C(C=C1)C2=C(SC(=N2)N(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)C5=CC=CC=C5
PubChem CID	134813912

References

1. Lewis TA, Bayless L, Eckman JB, Ellis JL, Grewal G, Libertine L, Marie Nicolas J, Scannell RT, Wels BF, Wenberg K et al.. (2004) 5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.. Bioorg Med Chem Lett, 14 (9): (2265-8). [PMID:15081022]
2. Sinha S, Doble M, Manju SL. (2018) Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.. Eur J Med Chem, 158 (3): (34-50). [PMID:30199704]
3. Malec J, Przybyszewski WM, Grabarczyk M, Sitarska E. (1984) Hydroxyurea has the capacity to induce damage to human erythrocytes which can be modified by radical scavengers.. Biochem Biophys Res Commun, 120 (2): (566-73). [PMID:6732772]
4. Brooks CD, Stewart AO, Basha A, Bhatia P, Ratajczyk JD, Martin JG, Craig RA, Kolasa T, Bouska JB, Lanni C et al.. (1995) (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.. J Med Chem, 38 (24): (4768-75). [PMID:7490726]

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Basic Description