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5-phenyl-N-(2-phenylethyl)-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]furo[3,2-e]pyrimidin-4-amine , CAS No.P609095, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of tyrosine kinase non receptor 2

  • Moligand™
Item Number
P609095
Grouped product items
SKUSizeAvailabilityPrice Qty
P609095-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,000.90
P609095-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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LCK proto-oncogene，Src family tyrosine kinase Inhibitor tyrosine kinase non receptor 2 Inhibitor

Basic Description

Synonymscompound 30
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of tyrosine kinase non receptor 2

Associated Targets

LCK Tclin Tyrosine-protein kinase Lck 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TNK2 Tclin Activated CDC42 kinase 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-phenyl-N-(2-phenylethyl)-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]furo[3,2-e]pyrimidin-4-amine
INCHI InChI=1S/C32H32N4O2/c1-3-9-24(10-4-1)17-18-33-31-29-28(25-11-5-2-6-12-25)30(38-32(29)35-23-34-31)26-13-15-27(16-14-26)37-22-21-36-19-7-8-20-36/h1-6,9-16,23H,7-8,17-22H2,(H,33,34,35)
InChi Key CYXPHNZJEDAZDD-UHFFFAOYSA-N
Canonical SMILES c1ccc(cc1)c1c(oc2c1c(NCCc1ccccc1)ncn2)c1ccc(cc1)OCCN1CCCC1
Isomeric SMILES C1CCN(C1)CCOC2=CC=C(C=C2)C3=C(C4=C(N=CN=C4O3)NCCC5=CC=CC=C5)C6=CC=CC=C6
PubChem CID 11540659

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Buchanan JL, Buckner WH, Cheng A, Faust T, Hsieh F et al..  (2007)  Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR..  Bioorg Med Chem Lett,  17  (8): (2305-9).  [PMID:17280833]

Solution Calculators

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