5(S),14(R)-Lipoxin B4 - A solution in ethanol,>95%, high purity , CAS No.98049-69-5

Item Number

R341887

Grouped product items
SKU	Size	Availability	Price	Qty
R341887-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$406.90
R341887-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$777.90

a positional isomer of LXA4

Basic Description

Synonyms	GTPL5216 \| AKOS040755843 \| Eicosanoids_LXB4_C20H32O5 \| CHEBI:6499 \| (5S,6E,8Z,10E,12E,14R,15S)-5,14,15-trihydroxyeicosa-6,8,10,12-tetraenoic acid \| C06315 \| (6E,8Z,10E,12E)-(5S,14R,15S)-Trihydroxyicosa-6,8,10,12-tetraenoate \| 5S,14R,15S-trihydroxy-6E,8Z,1
Specifications & Purity	Moligand™, ≥95%, A solution in ethanol
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	A positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. It is apart of a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC\|50\|value of ~3 X 10-10 M.

Names and Identifiers

IUPAC Name	(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid
INCHI	InChI=1S/C20H32O5/c1-2-3-8-14-18(22)19(23)15-10-7-5-4-6-9-12-17(21)13-11-16-20(24)25/h4-7,9-10,12,15,17-19,21-23H,2-3,8,11,13-14,16H2,1H3,(H,24,25)/b6-4-,7-5+,12-9+,15-10+/t17-,18+,19-/m1/s1
InChi Key	UXVRTOKOJOMENI-WLPVFMORSA-N
Canonical SMILES	CCCCCC(C(C=CC=CC=CC=CC(CCCC(=O)O)O)O)O
Isomeric SMILES	CCCCC[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](CCCC(=O)O)O)O)O
PubChem CID	5280915
Molecular Weight	352.47

CAS Registry No.

ChEBI

PubChem CID

Wikipedia

Refractive Index

n20D1.54 (Predicted)

Boil Point(°C)

78° C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Parkinson JF. (2006) Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation.. Inflamm Allergy Drug Targets, 5 (2): (91-106). [PMID:16613568] [10.1021/op500134e]
2. Karra L, Haworth O, Priluck R, Levy BD, Levi-Schaffer F. (2015) Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice.. Mucosal Immunol, 8 (4): (852-62). [PMID:25465102] [10.1021/op500134e]
3. Kim N, Lannan KL, Thatcher TH, Pollock SJ, Woeller CF, Phipps RP. (2018) Lipoxin B₄ Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression.. J Immunol, 201 (11): (3343-3351). [PMID:30348736] [10.1021/op500134e]

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Basic Description