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6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile , CAS No.D609118, Inhibitor of kallikrein related peptidase 4

  • Moligand™
Item Number
D609118
Grouped product items
SKUSizeAvailabilityPrice Qty
D609118-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609118-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
kallikrein related peptidase 4 Inhibitor

Basic Description

SynonymsCHEMBL578159|compound 33 [PMID: 19908842]|6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile|MLS002471784|GTPL8874|SCHEMBL3346407|CHEBI:92683|VMJFQUMKCMNFSX-UHFFFAOYSA-N|DTXSID401141962|HMS2213P07|HMS3348G08|BDBM50303436|NCGC00182115-01|NC
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of kallikrein related peptidase 4

Associated Targets

ELANE Tclin Neutrophil elastase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSZ Tchem Cathepsin Z 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSL Tclin Cathepsin L1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSS Tchem Cathepsin S 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSG Tchem Cathepsin G 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSC Tchem Dipeptidyl peptidase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP14 Tchem Matrix metalloproteinase-14 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CASP1 Tchem Caspase-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CMA1 Tchem Chymase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KLK4 Tchem Kallikrein-4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NPC1 Tchem NPC intracellular cholesterol transporter 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile
INCHI InChI=1S/C14H8F4N6/c15-7-1-8(16)3-9(2-7)21-13-12-14(23-11(4-19)22-13)24(6-20-12)5-10(17)18/h1-3,6,10H,5H2,(H,21,22,23)
InChi Key VMJFQUMKCMNFSX-UHFFFAOYSA-N
Canonical SMILES N#Cc1nc(Nc2cc(F)cc(c2)F)c2c(n1)n(cn2)CC(F)F
Isomeric SMILES C1=C(C=C(C=C1F)F)NC2=C3C(=NC(=N2)C#N)N(C=N3)CC(F)F
PubChem CID 44143089

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR et al..  (2010)  Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB..  J Med Chem,  53  (1): (52-60).  [PMID:19908842]

Solution Calculators

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