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6-α-Methylprednisolone - 98%, high purity , CAS No.83-43-2, Agonist of Glucocorticoid receptor;Activator of TRPC5
Basic Description Synonyms methylprednisolone|83-43-2|Medrol|Medrone|Metilprednisolone|6alpha-Methylprednisolone|Metilbetasone|Medrate|Urbason|Dopomedrol|Medesone|Mesopren|Metastab|Metrisone|Noretona|Promacortine|Urbasone|Besonia|Moderin|Solomet|Wyacort|Methylprednisolon|Sieropreso Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Storage Temp Store at 2-8°C,Protected from light Shipped In Wet ice Grade Moligand™ Action Type ACTIVATOR, AGONIST Mechanism of action Agonist of Glucocorticoid receptor;Activator of TRPC5
Names and Identifiers IUPAC Name (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one INCHI InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 InChi Key VHRSUDSXCMQTMA-PJHHCJLFSA-N Canonical SMILES CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O Isomeric SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O WGK Germany 2 RTECS TU4146000 PubChem CID 6741 Molecular Weight 374.47 Beilstein 2340300 Reaxy-Rn 2340300
Chemical and Physical Properties Solubility insoluble in H2O; ≥15.35 mg/mL in DMSO; ≥9.5 mg/mL in EtOH with ultrasonic Sensitivity Light sensitive Specific Rotation[α] 82° (C=1,Dioxane) Melt Point(°C) 237°C(lit.)
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H302: Harmful if swallowed
H312: Harmful in contact with skin
H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P317: Get emergency medical help.
P319: Get medical help if you feel unwell.
WGK Germany 2 RTECS TU4146000 Reaxy-Rn 2340300
References 1. Beckmann H, Richter J, Hill K, Urban N, Lemoine H, Schaefer M. (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels.. Cell Calcium, 66 (3): (10-18). [PMID:28807145 ]
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