Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
G111261-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $205.90 | |
G111261-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $923.90 |
Apoptotic, antioxidant and anti-inflammatory agent. SERCA activator.
Synonyms | 6-Gingerol|gingerol|23513-14-6|[6]-Gingerol|(6)-Gingerol|(S)-(+)-[6]Gingerol|(S)-(6)-Gingerol|(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one|(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one|1391-73-7|3-Decanone, 5-hydroxy-1-(4-hydroxy-3-met |
---|---|
Specifications & Purity | analytical standard,≥98% |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | analytical standard |
Action Type | ACTIVATOR |
Mechanism of action | Activator of TRPA1 |
Product Description | Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, has been shown to stimulate the Ca2+-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca2+-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it has been shown to have apoptotic properties. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one |
---|---|
INCHI | InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 |
InChi Key | NLDDIKRKFXEWBK-AWEZNQCLSA-N |
Canonical SMILES | CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
Isomeric SMILES | CCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
WGK Germany | 3 |
RTECS | HE0757000 |
PubChem CID | 442793 |
UN Number | 2811 |
Molecular Weight | 294.39 |
PubChem CID | 442793 |
---|---|
Wikipedia | Gingerol |
ChEBI | CHEBI:10136 |
CAS Registry No. | 23513-14-6 |
ChEMBL Ligand | CHEMBL402978 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2220602 | Certificate of Analysis | Apr 07, 2024 | G111261 |
C2429458 | Certificate of Analysis | Mar 08, 2024 | G111261 |
C2429463 | Certificate of Analysis | Mar 08, 2024 | G111261 |
C2407484 | Certificate of Analysis | Feb 28, 2024 | G111261 |
G2322734 | Certificate of Analysis | Jul 11, 2023 | G111261 |
G2322738 | Certificate of Analysis | Jul 11, 2023 | G111261 |
Solubility | Soluble in ethanol, benzene, ether, chloroform, methanol (1 mg/ml), and DMSO. Insoluble in water. |
---|---|
Sensitivity | Light & heat sensitive. |
Pictogram(s) | GHS06 |
---|---|
Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... |
WGK Germany | 3 |
RTECS | HE0757000 |
Starting at $90.90
1. Wala K et al.. (2022) Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma.. Molecules, 27 (9): [PMID:35566044] |