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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G422764-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $90.90 |
Apoptotic, antioxidant and anti-inflammatory agent. SERCA activator.
Synonyms | 6-Gingerol|gingerol|23513-14-6|[6]-Gingerol|(6)-Gingerol|(S)-(+)-[6]Gingerol|(S)-(6)-Gingerol|(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one|(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one|1391-73-7|3-Decanone, 5-hydroxy-1-(4-hydroxy-3-met |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Apoptotic, antioxidant and anti-inflammatory agent. SERCA activator (EC 50 = 4 μM, Ca 2+ ATPase in cardiac sarcoplasmic reticulum). Inhibts COX-2 expression. Blocks p38 MAP kinase activation. Shows antiangiogenic effects in vivo. Orally active. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, has been shown to stimulate the Ca2+-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca2+-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it has been shown to have apoptotic properties. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one |
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INCHI | InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 |
InChi Key | NLDDIKRKFXEWBK-AWEZNQCLSA-N |
Canonical SMILES | CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
Isomeric SMILES | CCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
WGK Germany | 3 |
RTECS | HE0757000 |
PubChem CID | 442793 |
UN Number | 2811 |
Molecular Weight | 294.39 |
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Sensitivity | Light & heat sensitive. |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... |
WGK Germany | 3 |
RTECS | HE0757000 |