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(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid - 98%, white, high purity , CAS No.53188-07-1

  • ≥98%
  • white
Item Number
T137260
Grouped product items
SKUSizeAvailabilityPrice Qty
T137260-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$17.90
T137260-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$58.90
T137260-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$177.90
T137260-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$711.90

Antioxidant vitamin E derivative

Basic Description

Synonymstrolox|53188-07-1|6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid|TROLOX C|6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid|3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid|56305-04-5|2H-1-Benzopyran-2-carboxylic a
Specifications & Purity≥98%, white
Biochemical and Physiological MechanismsAntioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
NoteThe appearance is white. If possible, try to prepare the solution on the day of use and finish it on the same day. However, if you need to prepare a stock solution in advance, we recommend that you store the solution in equal portions in sealed small bottles at -20 ° C. Usually, they can be used for up to one month. Before use and opening the sample bottle, we recommend that you allow your product to equilibrate at room temperature for at least 1 hour.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DHRS9 Tbio Dehydrogenase/reductase SDR family member 9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FDFT1 Tchem Squalene synthase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

XDH Tclin Xanthine dehydrogenase/oxidase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALB Tchem Serum albumin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1A1 Tchem Alcohol dehydrogenase [NADP(+)] 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ARNT Tbio Aryl hydrocarbon receptor nuclear translocator 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
INCHI InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChi Key GLEVLJDDWXEYCO-UHFFFAOYSA-N
Canonical SMILES CC1=C(C2=C(CCC(O2)(C)C(=O)O)C(=C1O)C)C
Isomeric SMILES CC1=C(C2=C(CCC(O2)(C)C(=O)O)C(=C1O)C)C
WGK Germany 2
RTECS DJ2273000
PubChem CID 40634
Molecular Weight 250.29
Beilstein 1384050
Reaxy-Rn 5052542

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

38 results found

Lot NumberCertificate TypeDateItem
E2430438Certificate of AnalysisMay 20, 2024 T137260
E2431269Certificate of AnalysisMay 20, 2024 T137260
J2325694Certificate of AnalysisOct 17, 2023 T137260
J2325693Certificate of AnalysisOct 17, 2023 T137260
I2327109Certificate of AnalysisSep 25, 2023 T137260
I2327108Certificate of AnalysisSep 25, 2023 T137260
F23161130Certificate of AnalysisJun 21, 2023 T137260
F23161139Certificate of AnalysisJun 21, 2023 T137260
F23161196Certificate of AnalysisJun 21, 2023 T137260
F23161137Certificate of AnalysisJun 20, 2023 T137260
F23161135Certificate of AnalysisJun 20, 2023 T137260
F23161134Certificate of AnalysisJun 20, 2023 T137260
F23161140Certificate of AnalysisJun 20, 2023 T137260
F2314816Certificate of AnalysisJun 10, 2023 T137260
F2314829Certificate of AnalysisJun 10, 2023 T137260
F2314830Certificate of AnalysisJun 10, 2023 T137260
F2314916Certificate of AnalysisJun 10, 2023 T137260
F2314918Certificate of AnalysisJun 10, 2023 T137260
E23081334Certificate of AnalysisApr 13, 2023 T137260
E23081333Certificate of AnalysisApr 13, 2023 T137260
E23081269Certificate of AnalysisApr 13, 2023 T137260
E23081193Certificate of AnalysisApr 13, 2023 T137260
B2310809Certificate of AnalysisJan 14, 2023 T137260
B2310811Certificate of AnalysisJan 14, 2023 T137260
B2310815Certificate of AnalysisJan 14, 2023 T137260
B2124222Certificate of AnalysisDec 08, 2022 T137260
H2219540Certificate of AnalysisAug 11, 2022 T137260
H2219548Certificate of AnalysisAug 11, 2022 T137260
J2021018Certificate of AnalysisAug 10, 2022 T137260
G2226101Certificate of AnalysisJul 28, 2022 T137260
G2207392Certificate of AnalysisJun 15, 2022 T137260
I2130124Certificate of AnalysisSep 15, 2021 T137260
I2130125Certificate of AnalysisSep 15, 2021 T137260
I2130126Certificate of AnalysisSep 15, 2021 T137260
I2130127Certificate of AnalysisSep 15, 2021 T137260
I2130128Certificate of AnalysisSep 15, 2021 T137260
J2228156Certificate of AnalysisSep 15, 2021 T137260
F2229129Certificate of AnalysisSep 15, 2021 T137260

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Chemical and Physical Properties

SolubilitySoluble in 100% ethanol (25 mg/ml), methanol, water(slightly 0.5mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml)
Sensitivityair sensitive;Hygroscopic
Melt Point(°C)187-189 °C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS DJ2273000
Reaxy-Rn 5052542

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References

1. Liu P et al..  (2017)  Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2..  Protein Cell,  (10): (735-749).  [PMID:28730546]
2. Wang T et al..  (2014)  Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction..  PLoS One,  (3): (e91063).  [PMID:24608713]
3. 刘松子.  (2024)  Mammalian IRE1α dynamically and functionally coalesces with stress granules.  Nature cell biology,  N/A  (N/A): (N/A).  [PMID:]

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