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(6S)-2-amino-3,6-dimethyl-6-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5H-pyrimidin-4-one , CAS No.1613380-81-6, Inhibitor of beta-secretase 1

(6S)-2-amino-3,6-dimethyl-6-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5H-pyrimidin-4-one , CAS No.1613380-81-6, Inhibitor of beta-secretase 1

Item Number

S608710

Grouped product items
SKU	Size	Availability	Price	Qty
S608710-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
S608710-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	CHEMBL2151141\|960075-53-0\|(6S)-2-amino-3,6-dimethyl-6-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5H-pyrimidin-4-one\|4(3H)-Pyrimidinone, 2-amino-5,6-dihydro-3,6-dimethyl-6-[4-[5-(1-propyn-1-yl)-3-pyridinyl]-2-thienyl]-, (6S)-\|1613380-81-6\|GTPL8399\|SCHEMB
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of beta-secretase 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(6S)-2-amino-3,6-dimethyl-6-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5H-pyrimidin-4-one
INCHI	InChI=1S/C18H18N4OS/c1-4-5-12-6-13(10-20-9-12)14-7-15(24-11-14)18(2)8-16(23)22(3)17(19)21-18/h6-7,9-11H,8H2,1-3H3,(H2,19,21)/t18-/m0/s1
InChi Key	IKFZEHQGULJMKI-SFHVURJKSA-N
Canonical SMILES	CC#Cc1cncc(c1)c1csc(c1)[C@]1(C)CC(=O)N(C(=N1)N)C
Isomeric SMILES	CC#CC1=CC(=CN=C1)C2=CSC(=C2)[C@@]3(CC(=O)N(C(=N3)N)C)C
PubChem CID	23627211

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1. Stamford AW, Scott JD, Li SW, Babu S, Tadesse D, Hunter R, Wu Y, Misiaszek J, Cumming JN, Gilbert EJ et al.. (2012) Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction.. ACS Med Chem Lett, 3 (11): (897-902). [PMID:23412139]
2. Menting KW, Claassen JA. (2014) β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease.. Front Aging Neurosci, 6 (3): (165). [PMID:25100992]

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