Skip to the beginning of the images gallery

7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyrazin-2-ylmethylamino)pyrido[3,4-b]pyrazin-2-one , CAS No.M609299, Inhibitor of phosphodiesterase 5A;Inhibitor of phosphodiesterase 6A

Moligand™

PubChem CID: 45486504

Item Number

M609299

Grouped product items
SKU	Size	Availability	Price	Qty
M609299-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M609299-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

phosphodiesterase 5A Inhibitor phosphodiesterase 6A Inhibitor

Synonyms

compound 53

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of phosphodiesterase 5A;Inhibitor of phosphodiesterase 6A

Associated Targets

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase 2 Activities

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE6A Tclin Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 2 Activities

Discover Target: PDE6A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyrazin-2-ylmethylamino)pyrido[3,4-b]pyrazin-2-one
INCHI	InChI=1S/C23H25N7O3/c1-3-9-33-10-8-30-20-11-18(16-4-5-21(32-2)27-12-16)26-15-19(20)29-22(23(30)31)28-14-17-13-24-6-7-25-17/h4-7,11-13,15H,3,8-10,14H2,1-2H3,(H,28,29)
InChi Key	HCCNBKFJYUWLEX-UHFFFAOYSA-N
Canonical SMILES	CCCOCCn1c2cc(ncc2nc(c1=O)NCc1cnccn1)c1ccc(nc1)OC
Isomeric SMILES	CCCOCCN1C2=CC(=NC=C2N=C(C1=O)NCC3=NC=CN=C3)C4=CN=C(C=C4)OC
PubChem CID	45486504

ChEMBL Ligand

CHEMBL567470

PubChem CID

45486504

BindingDB Ligand

50300972

References

1. Hughes RO, Walker JK, Rogier DJ, Heasley SE, Blevis-Bal RM, Benson AG, Jacobsen EJ, Cubbage JW, Fobian YM, Owen DR et al.. (2009) Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.. Bioorg Med Chem Lett, 19 (17): (5209-13). [PMID:19631533]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyrazin-2-ylmethylamino)pyrido[3,4-b]pyrazin-2-one , CAS No.M609299, Inhibitor of phosphodiesterase 5A;Inhibitor of phosphodiesterase 6A

Basic Description

Associated Targets

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase 2 Activities

PDE6A Tclin Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 2 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator