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7-Amino-4-methyl-3-coumarinylacetic acid(AMCA) - suitable for fluorescence,90% (HPLC), high purity , CAS No.106562-32-7
Basic Description Synonyms 106562-32-7 | 2-(7-Amino-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid | 7-Amino-4-methylcoumarin-3-acetic acid | 7-Amino-4-methyl-3-coumarinylacetic acid | AMCA acid | 2-(7-amino-4-methyl-2-oxochromen-3-yl)acetic acid | AMCA-H | 2H-1-Benzopyran-3-acetic acid, 7-amino-4-m Specifications & Purity suitable for fluorescence,90% (HPLC) Shipped In Normal Grade for fluorescence analysis Product Description Non-activated, Amine-reactive, fluorescent probe that can be conjugated to biomolecules. A blue fluorophore useful for immunofluorescence and peptide labeling.AMCA is a useful agent for labeling proteins. Demonstrates a characteristic absorption peak at 345 nm with a fluorescence emission at 440-460 nm (blue region); however, when conjugated with proteins the absorption peak shifts to 355 nm with a fluorescence emission at 440-460 nm. It has a high fluorescence yield with a sufficient Stokes shift (100 nm) and is relatively photostable.Relatively easy to activate and couple to the N-terminal amino group of a peptide resulting in an acid stable amide bond.
Fluorescence: λex 350 nm,λem 433 nm in methanol
Names and Identifiers IUPAC Name 2-(7-amino-4-methyl-2-oxochromen-3-yl)acetic acid INCHI InChI=1S/C12H11NO4/c1-6-8-3-2-7(13)4-10(8)17-12(16)9(6)5-11(14)15/h2-4H,5,13H2,1H3,(H,14,15) InChi Key QEQDLKUMPUDNPG-UHFFFAOYSA-N Canonical SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)N)CC(=O)O Isomeric SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)N)CC(=O)O WGK Germany 3 PubChem CID 129367 Molecular Weight 233.22 Beilstein 7927205
Chemical and Physical Properties Solubility Soluble in DMF, DMSO, aqueous base, 10% NaOH solution (freely soluble) at 20 °C, alcohol at 20 °C, acetone at 20 °C, and ether (slightly soluble) at 20 °C. Insoluble in water. Sensitivity Light & Moisture Sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
Citations of This Product 1. Ti Qin, Pinhao Li, Jun Li, Qianqian Guo, Ying Chen, Yu-E Wang, Ling Tao, Jian Huang, Xiangchun Shen, Xingjie Wu. (2023) Size-Exclusion Chromatography-Based Extracellular Vesicles Size Subtyping and Multiplex Membrane Protein Profiling for Differentiating Gastrointestinal Cancer Prognosis. ANALYST, [PMID:37842723 ]
References 1. Ti Qin, Pinhao Li, Jun Li, Qianqian Guo, Ying Chen, Yu-E Wang, Ling Tao, Jian Huang, Xiangchun Shen, Xingjie Wu. (2023) Size-Exclusion Chromatography-Based Extracellular Vesicles Size Subtyping and Multiplex Membrane Protein Profiling for Differentiating Gastrointestinal Cancer Prognosis. ANALYST, [PMID:37842723 ]
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