7-Hydroxy-DPAT·HBr - 98%, high purity , CAS No.74938-11-7, Agonist of D 2 receptor;Agonist of D 3 receptor

Item Number

H335872

• Synonyms: 76135-30-3|74938-11-7|7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide|7-Hydroxy-DPAT hydrobromide|159795-63-8|7-OH-dpat hydrobromide|R(+)-7-Hydroxy-DPAT hydrobromide|(+/-)-7-Hydroxy-DPAT hydrobromide|7-OH-DPAT (hydrobromide)|(R)-(+)-7-Hyd
• Specifications & Purity: Moligand™, ≥98%
• Storage Temp: Room temperature
• Shipped In: Normal
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of D 2 receptor;Agonist of D 3 receptor

Product Description

7-Hydroxy-DPAT·HBr is a selective D3DR (dopamine receptor) agonist that is primarily found in neurons of the brain. Upon activation by 7-Hydroxy-DPAT·HBr, D3DR's exhibit a decrease in the release of dopamine from neurons and activate phospholipase D via formation of a complex with RhoA. In addition, studies suggest that 7-Hydroxy-DPAT·HBr induces the suppression of cAMP in hamster ovary cells. Since the D3DR is part of the D2DR subfamily, which includes the D2DR, D3DR, and D4DR receptors, ligands such as 7-Hydroxy-DPAT·HBr can also bind to D2DR at a higher concentration. 7-Hydroxy-DPAT·HBr is an activator of D2DR.