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7-methoxy-3-methyl-2-[1-[[4-(trifluoromethoxy)phenyl]methyl]pyrazol-4-yl]-1H-quinolin-4-one , CAS No.M608651, Plasmodium falciparum cytochrome b

7-methoxy-3-methyl-2-[1-[[4-(trifluoromethoxy)phenyl]methyl]pyrazol-4-yl]-1H-quinolin-4-one , CAS No.M608651, Plasmodium falciparum cytochrome b

Item Number

M608651

Grouped product items
SKU	Size	Availability	Price	Qty
M608651-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M608651-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 11c
Grade	Moligand™
Mechanism of action	Plasmodium falciparum cytochrome b

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	7-methoxy-3-methyl-2-[1-[[4-(trifluoromethoxy)phenyl]methyl]pyrazol-4-yl]-1H-quinolin-4-one
INCHI	InChI=1S/C22H18F3N3O3/c1-13-20(27-19-9-17(30-2)7-8-18(19)21(13)29)15-10-26-28(12-15)11-14-3-5-16(6-4-14)31-22(23,24)25/h3-10,12H,11H2,1-2H3,(H,27,29)
InChi Key	CJKMEXVEIKDLMA-UHFFFAOYSA-N
Canonical SMILES	COc1ccc2c(c1)[nH]c(c(c2=O)C)c1cnn(c1)Cc1ccc(cc1)OC(F)(F)F
Isomeric SMILES	CC1=C(NC2=C(C1=O)C=CC(=C2)OC)C3=CN(N=C3)CC4=CC=C(C=C4)OC(F)(F)F
PubChem CID	67617845

RCSB PDB Ligand	FX2
PubChem CID	67617845

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1. Hong WD, Leung SC, Amporndanai K, Davies J, Priestley RS, Nixon GL, Berry NG, Hasnain SS, Antonyuk S, Ward SA et al.. (2018) Potent Antimalarial 2-Pyrazolyl Quinolone bc₁ (Q_i) Inhibitors with Improved Drug-like Properties.. ACS Med Chem Lett, 9 (12): (1205-1210). [PMID:30613327]

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