8-Chloroadenosine - ≥98%(HPLC), high purity , CAS No.34408-14-5

  • ≥98%(HPLC)
Item Number
C287342
Grouped product items
SKUSizeAvailabilityPrice Qty
C287342-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
C287342-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$155.90
C287342-10mg
10mg
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$208.90
C287342-25mg
25mg
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$419.90
C287342-50mg
50mg
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$869.90

Cytotoxic nucleoside analog; inhibits RNA synthesis

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Basic Description

SynonymsSCHEMBL987728 | (2R,3R,4S,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | UNII-PA05MFH3I7 | NSC-354258 | Q27286427 | AKOS024284395 | PA05MFH3I7 | 2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | AC-32299 | 8-Chloro
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsNucleoside analog; metabolizedin vivoto 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A5
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R,3R,4S,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
INCHI InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChi Key MHDPPLULTMGBSI-UUOKFMHZSA-N
Canonical SMILES C1=NC(=C2C(=N1)N(C(=N2)Cl)C3C(C(C(O3)CO)O)O)N
Isomeric SMILES C1=NC(=C2C(=N1)N(C(=N2)Cl)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N
PubChem CID 147569
Molecular Weight 301.69

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
C2414381Certificate of AnalysisFeb 01, 2024 C287342
C2414382Certificate of AnalysisFeb 01, 2024 C287342
C2414383Certificate of AnalysisFeb 01, 2024 C287342
C2414384Certificate of AnalysisFeb 01, 2024 C287342
C2414395Certificate of AnalysisFeb 01, 2024 C287342
C2414396Certificate of AnalysisFeb 01, 2024 C287342
C2414397Certificate of AnalysisFeb 01, 2024 C287342
C2414398Certificate of AnalysisFeb 01, 2024 C287342
C2414399Certificate of AnalysisFeb 01, 2024 C287342
C2414400Certificate of AnalysisFeb 01, 2024 C287342

Chemical and Physical Properties

SolubilitySolvent:water, Max Conc. mg/mL: 6.03, Max Conc. mM: 20 with gentle warming; Solvent:DMSO, Max Conc. mg/mL: 30.17, Max Conc. mM: 100
SensitivityLight sensitive

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Solution Calculators