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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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C287342-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
C287342-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $155.90 | |
C287342-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $208.90 | |
C287342-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $419.90 | |
C287342-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $869.90 |
Cytotoxic nucleoside analog; inhibits RNA synthesis
Synonyms | SCHEMBL987728 | (2R,3R,4S,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | UNII-PA05MFH3I7 | NSC-354258 | Q27286427 | AKOS024284395 | PA05MFH3I7 | 2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | AC-32299 | 8-Chloro |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Nucleoside analog; metabolizedin vivoto 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A5 |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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IUPAC Name | (2R,3R,4S,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
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INCHI | InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1 |
InChi Key | MHDPPLULTMGBSI-UUOKFMHZSA-N |
Canonical SMILES | C1=NC(=C2C(=N1)N(C(=N2)Cl)C3C(C(C(O3)CO)O)O)N |
Isomeric SMILES | C1=NC(=C2C(=N1)N(C(=N2)Cl)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N |
PubChem CID | 147569 |
Molecular Weight | 301.69 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
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C2414381 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414382 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414383 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414384 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414395 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414396 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414397 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414398 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414399 | Certificate of Analysis | Feb 01, 2024 | C287342 |
C2414400 | Certificate of Analysis | Feb 01, 2024 | C287342 |
Solubility | Solvent:water, Max Conc. mg/mL: 6.03, Max Conc. mM: 20 with gentle warming; Solvent:DMSO, Max Conc. mg/mL: 30.17, Max Conc. mM: 100 |
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Sensitivity | Light sensitive |