8-OH-DPAT - 97%, high purity , CAS No.78950-78-4, Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 5A receptor;Ago

Item Number

O414014

• Synonyms: 8-OH-Dpat|78950-78-4|8-Hydroxy-DPAT|8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN|7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol|DPAT|1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-|CHEMBL56|dl-8-Hydroxy-2-(dipropylamino)tetralin|1-Naphthalenol,7-(dip
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: 8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 5A receptor;Ago

Product Description

Information

8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic5-HT1Aagonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.

Targets

5-HT1A (Cell-free) 8.19(pIC50)

In vitro

The drug is only weakly effective at 5-HT1B subtype, the pIC50 being 5.42 ± 0.08 (n = 5). Since 8-OH-DPAT has no effect on 5-HT1B binding at concentrations lower than 100 nM. 8-OH-DPAT is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells.

In vivo

Intravenous administration of the selective 5-HT1A-receptor agonist 8-OH-DPAT rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability. 8-OH-DPAT is relatively lipophilic and readily crosses the blood-brain barrier.

Cell Research(from reference)

Cell lines：Retinal pigment epithelial (RPE) cells 

Concentrations：10 μM 

Incubation Time：24 h