Click Here for 5% Off Your First Aladdin Purchase!

A-205804 - ≥98%, high purity , CAS No.251992-66-2

  • ≥98%
Item Number
A129416
Grouped product items
SKUSizeAvailabilityPrice Qty
A129416-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$118.90
A129416-50mg
50mg
In stock
$478.90

Selective inhibitor of E-selectin and ICAM-1 expression

View related series
Bioactive compounds

Basic Description

Synonyms251992-66-2|A-205804|4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide|A 205804|4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide|TP7TB1SSZD|CHEMBL267678|A205804|4-((4-Methylphenyl)thio)thieno(2,3-C)pyridine-2-carboxamide|4-(4-methylphenyl)sulf
Specifications & Purity≥98%
Biochemical and Physiological MechanismsSelective inhibitor of E-selectin and ICAM-1 expression (IC50values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in anin vitroflow experiment.
Storage TempStore at 2-8°C
Shipped InWet ice
Note卖完停产,不再备货
Product Description

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
A selective inhibitor of E-selectin and ICAM-1 expression.

Associated Targets

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SELE Tchem E-selectin 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VCAM1 Tchem Vascular cell adhesion protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ICAM1 Tchem Intercellular adhesion molecule 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide
INCHI InChI=1S/C15H12N2OS2/c1-9-2-4-10(5-3-9)19-13-7-17-8-14-11(13)6-12(20-14)15(16)18/h2-8H,1H3,(H2,16,18)
InChi Key QQGWEXFLMJGCAL-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N
Isomeric SMILES CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N
PubChem CID 9839311
Molecular Weight 300.39

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
E1519010Certificate of AnalysisNov 14, 2022 A129416
C2211361Certificate of AnalysisMay 31, 2022 A129416

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 30.04, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3, Max Conc. mM: 10
SensitivityHeat Sensitive
Melt Point(°C)200 °C

Related Documents

Solution Calculators