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A-317491 - ≥98%, high purity , CAS No.475205-49-3, Antagonist of P2X3

Moligand™
≥98%

CAS#: 475205-49-3
Formula: C₃₃H₂₇NO₈
Molecular Weight: 565.57
PubChem CID: 9829395

Item Number

A126016

Grouped product items
SKU	Size	Availability	Price
A126016-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$78.90
A126016-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$246.90
A126016-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$593.90

View related series

P2X3 Antagonist

Basic Description

Synonyms	A-317491\|475205-49-3\|475205-49-3 (free acid)\|1,2,4-Benzenetricarboxylic acid, 5-((((3-phenoxyphenyl)methyl)((1S)-1,2,3,4-tetrahydro-1-naphthalenyl)amino)carbonyl)-\|H327N08IPV\|5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}be
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indic
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2X3
Note	卖完停产，不再备货
Product Description	A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. A P2X3 and P2X2/3 receptor antagonist

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX3 Tclin P2X purinoceptor 3 5 Activities

Discover Target: P2RX3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX2 Tchem P2X purinoceptor 2 0 Activities

Discover Target: P2RX2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid
INCHI	InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1
InChi Key	VQGBOYBIENNKMI-LJAQVGFWSA-N
Canonical SMILES	C1CC(C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O
Isomeric SMILES	C1C[C@@H](C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O
Alternate CAS	475205-49-3
PubChem CID	9829395
MeSH Entry Terms	A-317491;A317491
Molecular Weight	565.57

PubChem CID

ChEMBL Ligand

CAS Registry No.

RCSB PDB Ligand

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Lot Number	Certificate Type	Date	Item
H1722064	Certificate of Analysis	Feb 07, 2023	A126016

References

1. González-Rodríguez S, Pevida M, Roques BP, Fournié-Zaluski MC, Hidalgo A, Menéndez L, Baamonde A. (2009) Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.. Neurosci Lett, 465 (3): (285-9). [PMID:19765404]

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