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A 425619 - 95%, high purity , CAS No.581809-67-8, Channel blocker of TRPV1

  • ≥95%
Item Number
A288088
Grouped product items
SKUSizeAvailabilityPrice Qty
A288088-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
A288088-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$164.90
A288088-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$263.90
A288088-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$527.90
A288088-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$843.90
A288088-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,349.90

Potent TRPV1 antagonist

View related series
TRP Channel TRPV1 Channel blocker

Basic Description

Synonyms581809-67-8|A-425619|1-(4-(trifluoromethyl)benzyl)-3-(isoquinolin-5-yl)urea|1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea|1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea|A 425619|N2NOA4CE04|CHEMBL104028|A425619|1-Isoquinolin-5-yl-3-(4-
Specifications & Purity95%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of TRPV1
Product Description

A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain.

Associated Targets

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 11 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea
INCHI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)
InChi Key SJGVXVZUSQLLJB-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C=CN=C2)C(=C1)NC(=O)NCC3=CC=C(C=C3)C(F)(F)F
Isomeric SMILES C1=CC2=C(C=CN=C2)C(=C1)NC(=O)NCC3=CC=C(C=C3)C(F)(F)F
PubChem CID 8068410
Molecular Weight 345.32

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
E2422402Certificate of AnalysisFeb 26, 2024 A288088
E2422442Certificate of AnalysisFeb 26, 2024 A288088
E2422447Certificate of AnalysisFeb 26, 2024 A288088
E2422462Certificate of AnalysisFeb 26, 2024 A288088
E2422464Certificate of AnalysisFeb 26, 2024 A288088
E2422465Certificate of AnalysisFeb 26, 2024 A288088
E2422477Certificate of AnalysisFeb 26, 2024 A288088
E2422481Certificate of AnalysisFeb 26, 2024 A288088
E2422509Certificate of AnalysisFeb 26, 2024 A288088
E2422511Certificate of AnalysisFeb 26, 2024 A288088
E2422512Certificate of AnalysisFeb 26, 2024 A288088
E2422523Certificate of AnalysisFeb 26, 2024 A288088

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 34.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 34.53, Max Conc. mM: 100

Related Documents

Solution Calculators