| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A408570-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $393.90 |
TGFβRI/ALK5 Selective Inhibitors
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | Information A-83-01 is a potent inhibitor ofTGF-β type I receptor (ALK5-TD)with IC50 of 12 nM. A-83-01 also inhibits the transcription induced byactivin/nodal type I receptor (ALK4-TD)andnodal type I receptor (ALK7-TD)with IC50 of 45 nM and 7.5 nM, respectively.Solut A-83-01 inhibits the transcriptional activity induced by TGF-β type I receptor ALK-5 and that by activin type IB receptor ALK-4 and nodal type I receptor ALK-7, the kinase domains of which are structurally highly related to those of ALK-5. A-83-01 is potent in the inhibition of ALK5 and also prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-β. In vivo A83-01 treatment significantly increases the number of Nkx2.5+ cardiomyoblasts at baseline and after myocardial injury, resulting in an increase in newly formed cardiomyocytes. A83-01 treatment significantly improves ventricular elastance and stroke work, leading to improved contractility after injury. cell lines： Concentrations：1 μM Incubation Time：1 h Powder Purity: |
| Canonical SMILES | CC1=CC=CC(=N1)C2=N[N](C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 |
|---|---|
| Molecular Weight | 421.52 |
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| Solubility | Solubility (25°C) In vitro DMSO: 47 mg/mL (197.28 mM); |
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