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A-867744 - ≥98%, high purity , CAS No.1000279-69-5, Channel blocker of nicotinic acetylcholine receptor α3 subunit;Channel blocker of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit

Moligand™
≥98%

CAS#: 1000279-69-5
Formula: C₂₀H₁₉ClN₂O₃S
Molecular Weight: 402.89
PubChem CID: 23642319

Item Number

A127582

Grouped product items
SKU	Size	Availability	Price
A127582-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$53.90
A127582-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$222.90
A127582-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$741.90

Positive allosteric modulator of α7 nAChRs

View related series

nicotinic acetylcholine receptor α3 subunit Channel blocker nicotinic acetylcholine receptor α4 subunit Channel blocker nicotinic acetylcholine receptor α7 subunit Allosteric modulator

Basic Description

Synonyms	A-867744\|1000279-69-5\|4-(5-(4-Chlorophenyl)-2-methyl-3-propionylpyrrol-1-yl)benzenesulfonamide\|A 867744\|CHEMBL490153\|O6NW23A765\|Benzenesulfonamide, 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]-\|Benzenesulfonamide, 4-(5-(4-chlorophenyl)-2
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Positive allosteric modulator ofα7 nAChRs (IC50values are 0.98 and 1.12μM for human and ratα7 receptor ACh-evoked currents respectively, inX. laevisoocytes). Displays no activity at 5-HT3A,α3β4 orα4β2 nAChRs. Brain penetrant.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR, CHANNEL BLOCKER
Mechanism of action	Channel blocker of nicotinic acetylcholine receptor α3 subunit;Channel blocker of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit
Note	卖完停产，不再备货
Product Description	A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs.

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 4 Activities

Discover Target: CHRNA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA3 Tclin Neuronal acetylcholine receptor subunit alpha-3 0 Activities

Discover Target: CHRNA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNB2 Tclin Neuronal acetylcholine receptor subunit beta-2 0 Activities

Discover Target: CHRNB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA4 Tclin Neuronal acetylcholine receptor subunit alpha-4 0 Activities

Discover Target: CHRNA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[5-(4-chlorophenyl)-2-methyl-3-propanoylpyrrol-1-yl]benzenesulfonamide
INCHI	InChI=1S/C20H19ClN2O3S/c1-3-20(24)18-12-19(14-4-6-15(21)7-5-14)23(13(18)2)16-8-10-17(11-9-16)27(22,25)26/h4-12H,3H2,1-2H3,(H2,22,25,26)
InChi Key	ABACVOXFUHDKNZ-UHFFFAOYSA-N
Canonical SMILES	CCC(=O)C1=C(N(C(=C1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)S(=O)(=O)N)C
Isomeric SMILES	CCC(=O)C1=C(N(C(=C1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)S(=O)(=O)N)C
PubChem CID	23642319
Molecular Weight	402.89

PubChem CID

23642319

ChEMBL Ligand

CHEMBL490153

CAS Registry No.

1000279-69-5

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
L2315078	Certificate of Analysis	Dec 28, 2023	A127582
D1725129	Certificate of Analysis	Nov 16, 2022	A127582

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