A 971432 - 98%, high purity , CAS No.1240308-45-5, Agonist of S1P 1 receptor;Agonist of S1P 5 receptor

Item Number

A287220

Grouped product items
SKU	Size	Availability	Price	Qty
A287220-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$141.90
A287220-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$590.90

Potent and selective S1P5agonist

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Basic Description

Synonyms	1240308-45-5\|A-971432\|A971432\|1-({4-[(3,4-dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid\|CHEMBL3741589\|A 971432\|1-(4-(3,4-dichlorobenzyloxy)benzyl)azetidine-3-carboxylic acid\|1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Ac
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) withou
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of S1P 1 receptor;Agonist of S1P 5 receptor

Names and Identifiers

IUPAC Name	1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]azetidine-3-carboxylic acid
INCHI	InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23)
InChi Key	WAAWETUDFSIYSD-UHFFFAOYSA-N
Canonical SMILES	C1C(CN1CC2=CC=C(C=C2)OCC3=CC(=C(C=C3)Cl)Cl)C(=O)O
Isomeric SMILES	C1C(CN1CC2=CC=C(C=C2)OCC3=CC(=C(C=C3)Cl)Cl)C(=O)O
Alternate CAS	1240308-45-5
PubChem CID	46872626
Molecular Weight	366.24

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
B2418022	Certificate of Analysis	Jan 03, 2024	A287220
B2418023	Certificate of Analysis	Jan 03, 2024	A287220
B2418024	Certificate of Analysis	Jan 03, 2024	A287220
B2418025	Certificate of Analysis	Jan 03, 2024	A287220

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
RIDADR	NONHforallmodesoftransport

References

1. Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G et al.. (2015) Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.. J Med Chem, 58 (23): (9154-70). [PMID:26509640]

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Basic Description