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α-Cyano-4-hydroxycinnamic Acid - 98%, high purity , CAS No.28166-41-8, Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2

23 Citations
Item Number
A151195
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A151195-200mg
200mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$22.90
A151195-1g
1g
In stock
$86.90
A151195-5g
5g
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$389.90
A151195-25g
25g
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$1,750.90
A151195-100g
100g
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$6,302.90
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Monocarboxylic acid transport inhibitor

View related series
Membrane Transporter/Ion Channel mitochondrial pyruvate carrier 1 Inhibitor mitochondrial pyruvate carrier 2 Inhibitor Monocarboxylate Transporter

Basic Description

SynonymsNCGC00094622-01 | AMY11197 | BRD-K60302405-001-02-9 | Dimethiotazine | DTXSID501018295 | MLS002207285 | (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid | 2-Cyano-3-(4-hydroxyphenyl)propenoic acid | 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid | a-Cyano-
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsMonocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo . Decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of the DNA-methylating antitumor agent temozol
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Introduction

α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase.


Application

α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Associated Targets(Human)

MPC2 Tbio Mitochondrial pyruvate carrier 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MPC1 Tbio Mitochondrial pyruvate carrier 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SiHa (2051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A7 Tchem Monocarboxylate transporter 2 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNK2 Potassium channel subfamily K member 2 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488195368
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195368
IUPAC Name (E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid
INCHI InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChi Key AFVLVVWMAFSXCK-VMPITWQZSA-N
Canonical SMILES C1=CC(=CC=C1C=C(C#N)C(=O)O)O
Isomeric SMILES C1=CC(=CC=C1/C=C(\C#N)/C(=O)O)O
WGK Germany 3
PubChem CID 5328791
Molecular Weight 189.17
Beilstein 3271430

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
C2306918Certificate of AnalysisMar 09, 2023 A151195
C2306919Certificate of AnalysisJul 15, 2022 A151195
H2428037Certificate of AnalysisJul 15, 2022 A151195
I2209074Certificate of AnalysisJul 15, 2022 A151195
I2209075Certificate of AnalysisJul 15, 2022 A151195
I2209076Certificate of AnalysisJul 15, 2022 A151195
I2209077Certificate of AnalysisJul 15, 2022 A151195
K2408164Certificate of AnalysisJul 15, 2022 A151195
C2306920Certificate of AnalysisOct 09, 2021 A151195

Chemical and Physical Properties

Melt Point(°C)245-250℃

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

Citations of This Product

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2. Chenhui Lu, Haodong Wei, Lizhi Xu, Wen-Long Wang, Cheng Yang, Xueli Shi, Hui Gao, Yong-Wei Feng, Jianzhong Zhou, Yi Zhang.  (2024)  Enrichment of sialic acid-containing casein glycomacropeptide in protein hydrolysates using phenylboronic acid-functionalized mesoporous silica nanoparticles.  TALANTA,  267  (27): (125174).  [PMID:37708769] [10.1016/j.talanta.2023.125174]
3. Lei Wang, Yuhao Han, Yaqi Zhang, Haoyuan Geng, Zihan Zhu, Panpan Chen, Xiaoqing Cui, Xiao Wang, Chenglong Sun.  (2023)  In-depth profiling of carbohydrate isomers in biological tissues by chemical derivatization-assisted mass spectrometry imaging.  ANALYTICA CHIMICA ACTA,  1278  (341741).  [PMID:37709472] [10.1016/j.aca.2023.341741]
4. Xirui Duan, Hailong Tian, Shuwen Zheng, Jianmei Zhu, Chan Li, Bo He, Lei Li, Hao Jiang, Shuaijun Lu, Yumei Feng, Gary T. Bentley, Wei Zhang, Canhua Huang, Wei Gao, Na Xie, Ke Xie.  (2023)  Photothermal-Starvation Therapy Nanomodulator Capable of Inhibiting Colorectal Cancer Recurrence and Metastasis by Energy Metabolism Reduction.  Advanced Healthcare Materials,    (2300968).  [PMID:37543843] [10.1002/adhm.202300968]
5. Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang, Xia Wu.  (2023)  Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase.  CNS Neuroscience & Therapeutics,      [PMID:37528534] [10.1111/cns.14383]
6. Qi Meng, Jia Tan, Weifang Tong, Changxiao Chen, Zhendong Liu, Sainan Liu, Meifang Wang, Ziyong Cheng, Binbin Ding, Ping'an Ma, Jun Lin.  (2023)  Ultrafast self-assembled supramolecular nanoparticles for enhanced chemodynamic therapy and ferroptosis through lactic acid metabolism regulation.  CHEMICAL ENGINEERING JOURNAL,  471  (144563).  [PMID:] [10.1016/j.cej.2023.144563]
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10. Wenya Shao, Ying Sun, Hang Su, Qianqian Sun, Zian Lin.  (2022)  4-Mercaptobenzoic acid-assisted laser desorption/ionization mass spectrometry for sensitive quantification of cesium and strontium in drinking water.  RAPID COMMUNICATIONS IN MASS SPECTROMETRY,  36  (17): (e9342).  [PMID:35729806] [10.1002/rcm.9342]
11. Shuzhen Dou, Zhongshun Wang, Qiye Chen, Nan Lu.  (2022)  One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection.  SENSORS AND ACTUATORS B-CHEMICAL,  359  (131578).  [PMID:] [10.1016/j.snb.2022.131578]
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15. Chen Ya-Shun, Feng Yu-Qi.  (2022)  Rapid Determination of Endogenous 20-Hydroxyecdysone in Plants on MALDI-TOF/TOF Mass Spectrometry via Chemical Labeling Based on Boronate Affinity.  Journal of Analysis and Testing,  6  (3): (318-326).  [PMID:] [10.1007/s41664-021-00179-8]
16. Chenglong Sun, Shuangshuang Ma, Lili Li, Daijie Wang, Wei Liu, Feng Liu, Lanping Guo, Xiao Wang.  (2021)  Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging.  Journal of Ginseng Research,  45  (726).  [PMID:34764727] [10.1016/j.jgr.2021.04.001]
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18. Xiao-Cong Zhang, Song-Hai Wu, Shao-Yi Jia, Cong Wang, Shi-Wei Sun, Xiang-Ming Wang, Zi-He Meng, Yi-Ying Lin, Yong Liu, Hai-Tao Ren, Xu Han.  (2020)  Turning thiophene contaminant into polymers from wastewater by persulfate and CuO.  CHEMICAL ENGINEERING JOURNAL,  397  (125351).  [PMID:] [10.1016/j.cej.2020.125351]
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20. Chen Ya-Shun, Ding Jun, He Xiao-Mei, Xu Jing, Feng Yu-Qi.  (2018)  Synthesis of tellurium nanosheet for use in matrix assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules.  MICROCHIMICA ACTA,  185  (8): (1-9).  [PMID:29987637] [10.1007/s00604-018-2882-7]
21. Jun Ding, Simin Liu, Hua-Ming Xiao, Tian-tian Ye, Ping Zhou, Yu-Qi Feng.  (2017)  Matrix-assisted laser desorption/ionization mass spectrometry for the analysis of polyamines in plant micro-tissues using cucurbituril as a host molecule.  ANALYTICA CHIMICA ACTA,  987  (56).  [PMID:28916040] [10.1016/j.aca.2017.08.027]
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