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α-Cyano-4-hydroxycinnamic Acid - 98%, high purity , CAS No.28166-41-8, Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2

Moligand™
≥98%

CAS#: 28166-41-8
Formula: C₁₀H₇NO₃
Molecular Weight: 189.17
Beilstein Registry Number: 3271430
MDL number: MFCD00004204
PubChem CID: 5328791
PubChem SID: 488195368

Item Number

A151195

Grouped product items
SKU	Size	Availability	Price
A151195-200mg	200mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$22.90
A151195-1g	1g	In stock	$86.90
A151195-5g	5g	In stock	$389.90
A151195-25g	25g	In stock	$1,750.90
A151195-100g	100g	In stock	$6,302.90

Monocarboxylic acid transport inhibitor

View related series

mitochondrial pyruvate carrier 1 Inhibitor mitochondrial pyruvate carrier 2 Inhibitor

Basic Description

Synonyms	alpha-cyano-4-hydroxycinnamic acid\|28166-41-8\|a-Cyano-4-hydroxycinnamic acid\|alpha-Cyano\|122520-77-8\|(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid\|CHCA\|(E)-2-cyano-3-(4-hydroxyphenyl)acrylic acid\|(E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid\|alpha-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo . Decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of the DNA-methylating antitumor agent temozol
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Introduction α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase. Application α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR35 Tchem G-protein coupled receptor 35 0 Activities

Discover Target: GPR35

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPC2 Tbio Mitochondrial pyruvate carrier 2 0 Activities

Discover Target: MPC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK2 Tclin Potassium channel subfamily K member 2 0 Activities

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A7 Tchem Monocarboxylate transporter 2 0 Activities

Discover Target: SLC16A7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPC1 Tbio Mitochondrial pyruvate carrier 1 0 Activities

Discover Target: MPC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A3 Tchem Monocarboxylate transporter 4 0 Activities

Discover Target: SLC16A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A1 Tchem Monocarboxylate transporter 1 0 Activities

Discover Target: SLC16A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488195368
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195368
IUPAC Name	(E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid
INCHI	InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChi Key	AFVLVVWMAFSXCK-VMPITWQZSA-N
Canonical SMILES	C1=CC(=CC=C1C=C(C#N)C(=O)O)O
Isomeric SMILES	C1=CC(=CC=C1/C=C(\C#N)/C(=O)O)O
WGK Germany	3
PubChem CID	5328791
Molecular Weight	189.17
Beilstein	3271430

Database links

PubChem CID	2102
CAS Registry No.	28166-41-8
PubChem SID	488195368

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot Number	Certificate Type	Date	Item
C2306918	Certificate of Analysis	Mar 09, 2023	A151195
C2306919	Certificate of Analysis	Jul 15, 2022	A151195
H2428037	Certificate of Analysis	Jul 15, 2022	A151195
I2209074	Certificate of Analysis	Jul 15, 2022	A151195
I2209075	Certificate of Analysis	Jul 15, 2022	A151195
I2209076	Certificate of Analysis	Jul 15, 2022	A151195
I2209077	Certificate of Analysis	Jul 15, 2022	A151195
C2306920	Certificate of Analysis	Oct 09, 2021	A151195

Chemical and Physical Properties

Melt Point(°C)	245-250℃

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

References

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