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α-Hydroxy-γ-butyrolactone - technical grade, high purity , CAS No.19444-84-9
Basic Description Synonyms 3-hydroxydihydrofuran-2-one | Dihydro-3-hydroxy-2(3H)-furanone | s8103 | SY052569 | 3-Hydroxytetrahydrofuran-2-one | FT-0605147 | 2-HYDROXY-.GAMMA.-BUTYROLACTONE, (+/-)- | Ibrutinib (JAN/USAN) | CS-W013699 | DTXSID00941181 | EC 692-561-9 | 3-Hydroxydihydr Specifications & Purity technical grade Grade technical grade Product Description Description
α-Hydroxy-γ-butyrolactone is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde.α-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.
Names and Identifiers IUPAC Name 3-hydroxyoxolan-2-one INCHI InChI=1S/C4H6O3/c5-3-1-2-7-4(3)6/h3,5H,1-2H2 InChi Key FWIBCWKHNZBDLS-UHFFFAOYSA-N Canonical SMILES C1COC(=O)C1O Isomeric SMILES C1COC(=O)C1O WGK Germany 3 PubChem CID 545831 Molecular Weight 102.09 Beilstein 80587 Reaxy-Rn 80587
Chemical and Physical Properties Refractive Index 1.476-1.481 Flash Point(°F) 113 °C Flash Point(°C) 113°C Boil Point(°C) 133 °C/10 mmHg
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 Reaxy-Rn 80587
References 1. Sho Yamaguchi, Ken Motokura, Yasuharu Sakamoto, Akimitsu Miyaji, Toshihide Baba,. (2014-03-29) Tin-catalyzed conversion of biomass-derived triose sugar and formaldehyde to α-hydroxy-γ-butyrolactone.. Chemical communications (Cambridge, England), 50 ((35)): ( 4600-4602 ). [PMID:24668044 ]
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