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ABBV-318 - 98%, high purity , CAS No.1802848-94-7, Channel blocker of Na v1.7;Channel blocker of Na v1.8

  • Moligand™
  • ≥98%
Item Number
A607321
Grouped product items
SKUSizeAvailabilityPrice Qty
A607321-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$96.90
A607321-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
A607321-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$359.90
A607321-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$619.90
A607321-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$869.90

Basic Description

SynonymsABBV318;compound 73
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of Na v1.7;Channel blocker of Na v1.8
Product Description

ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain.

Associated Targets

SCN10A Tclin Sodium channel protein type 10 subunit alpha 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SCN9A Tclin Sodium channel protein type 9 subunit alpha 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES O=C(N1C[C@H](F)CC1)C2=NC3=CC=C(OC4=NC=C(C(F)(F)F)C=C4)C=C3C=C2
Molecular Weight 405.35

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
C2414192Certificate of AnalysisFeb 02, 2024 A607321
C2414193Certificate of AnalysisFeb 02, 2024 A607321
C2414194Certificate of AnalysisFeb 02, 2024 A607321
C2414195Certificate of AnalysisFeb 02, 2024 A607321

Related Documents

References

1. Patel MV, Peltier HM, Matulenko MA, Koenig JR, C Scanio MJ, Gum RJ, El-Kouhen OF, Fricano MM, Lundgaard GL, Neelands T et al..  (2022)  Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain..  Bioorg Med Chem,  63  (3): (116743).  [PMID:35436748]

Solution Calculators