Abciximab (anti-Integrin αIIbβ3) - Primary antibody, specific to Integrin αIIbβ3 (ITGA2B&ITGB3), Human IgG1, INHIBITOR of Integrin alpha-IIb/beta-3 inhibitor
Abciximab (anti-Integrin αIIbβ3) - Primary antibody, specific to Integrin αIIbβ3 (ITGA2B&ITGB3), Human IgG1, INHIBITOR of Integrin alpha-IIb/beta-3 inhibitor
Abciximab (anti-Integrin αIIbβ3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab (anti-Integrin αIIbβ3) inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors. Purity ≥95% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg Protein Function ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. ITGB3: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Product Properties
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
47.6 kDa
Purification Method
Protein A purified
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
143653-53-6
Images
Abciximab (anti-Integrin αIIbβ3) (Ab183009) - ELISA Immobilized Recombinant Human Integrin alpha 2b beta 3(ITGAIIb&ITGB3) Heterodimer protein at 2.0 μg/mL can bind Abciximab (anti-Integrin αIIbβ3) (Ab183009) with the EC₅₀ of 555.4 ng/mL.
Abciximab (anti-Integrin αIIbβ3) (Ab183009) - SEC The purity of Abciximab (anti-Integrin αIIbβ3) (Ab183009) is more than 95% verified by HPLC.