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Abiraterone - ≥99%, high purity , Steroid 5-alpha-reductase inhibitor, CAS No.154229-19-3, Steroid 5-alpha-reductase inhibitor
Basic Description Synonyms Abiraterone|154229-19-3|CB 7598|CB-7598|17-(3-Pyridyl)androsta-5,16-dien-3beta-ol|(3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol|Abiraterone (CB-7598)|CB7598|UNII-G819A456D0|CHEBI:68642|(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9 Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Abiraterone (CB-7598, CB7598, CB 7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer.
Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Steroid 5-alpha-reductase inhibitor Product Description Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM.
Names and Identifiers IUPAC Name (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol INCHI InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1 InChi Key GZOSMCIZMLWJML-VJLLXTKPSA-N Canonical SMILES CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O Isomeric SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O PubChem CID 132971 Molecular Weight 349.52
Chemical and Physical Properties Solubility DMSO 0.1 mg/mL Water 0.02 mg/mL Ethanol 0.2 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H360F: May damage fertility
H360: May damage fertility or the unborn child
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P391: Collect spillage.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
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A1514052