ABT-384 , 11-beta-hydroxysteroid dehydrogenase 1 inhibitor, CAS No.868623-40-9, 11-beta-hydroxysteroid dehydrogenase 1 inhibitor

Item Number

A607338

Grouped product items
SKU	Size	Availability	Price	Qty
A607338-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607338-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90

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Basic Description

Synonyms	ABT-384\|868623-40-9\|4-[[2-methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide\|CHEMBL222670\|ABT 384\|R5TH77F919\|SCHEMBL231595\|UNII-R5TH77F919\|ABT384\|GTPL7357\|CHEMBL4297256\|SCHEMBL20457214\|CLHMYBJIOZXCEX-MALZW
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	11-beta-hydroxysteroid dehydrogenase 1 inhibitor

Names and Identifiers

IUPAC Name	4-[[2-methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide
INCHI	InChI=1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)
InChi Key	CLHMYBJIOZXCEX-UHFFFAOYSA-N
Canonical SMILES	O=C(C(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)(C)C)NC1C2CC3CC1CC(C2)(C3)C(=O)N
Isomeric SMILES	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)N)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F
PubChem CID	11670435
Molecular Weight	493.6

PubChem CID

CAS Registry No.

References

1. Sorensen B, Rohde J, Wang J, Fung S, Monzon K, Chiou W, Pan L, Deng X, Stolarik D, Frevert EU et al.. (2006) Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.. Bioorg Med Chem Lett, 16 (23): (5958-62). [PMID:16996734]
2. An G, Liu W, Katz DA, Marek G, Awni W, Dutta S. (2013) Effect of ketoconazole on the pharmacokinetics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 and its two active metabolites in healthy volunteers: population analysis of data from a drug-drug interaction study.. Drug Metab Dispos, 41 (5): (1035-45). [PMID:23431112]
3. Katz DA, Liu W, Locke C, Jacobson P, Barnes DM, Basu R, An G, Rieser MJ, Daszkowski D, Groves F et al.. (2013) Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384.. Transl Psychiatry, 3 (3): (e295). [PMID:23982627]
4. Marek GJ, Katz DA, Meier A, Greco 4th N, Zhang W, Liu W, Lenz RA. (2014) Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease.. Alzheimers Dement, 10 (5 Suppl): (S364-73). [PMID:24418055]

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Basic Description