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AC 265347 - ≥99%(HPLC), high purity , CAS No.1253901-26-6, Allosteric modulator of CaS receptor

Moligand™
≥97%

CAS#: 1253901-26-6
Formula: C₁₇H₁₇NOS
Molecular Weight: 283.39
EC Number: 694-385-8
PubChem CID: 52943938

Item Number

A288466

Grouped product items
SKU	Size	Availability	Price
A288466-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$112.90
A288466-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$176.90
A288466-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$352.90
A288466-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$565.90
A288466-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$919.90

Biased allosteric modulator of calcium-sensing receptor (CaSR)

View related series

CaS receptor Allosteric modulator

Basic Description

Synonyms	AC-265347\|1253901-26-6\|AC265347\|1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol\|AC 265347\|1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethan-1-ol\|MLS006010713\|GTPL3947\|CHEMBL1256367\|SCHEMBL19462840\|AKOS027324495\|NCGC00344509-01\|SMR004701681\|HY-
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	CaSR biased allosteric modulator (pEC50= 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of CaS receptor
Product Description	Biased allosteric modulator of calcium-sensing receptor (CaSR) Application： AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.

Associated Targets

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

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GPR35 Tchem G-protein coupled receptor 35 0 Activities

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BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities

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FFAR4 Tchem Free fatty acid receptor 4 0 Activities

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FPR2 Tchem N-formyl peptide receptor 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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CASR Tclin Extracellular calcium-sensing receptor 1 Activities

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

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APLNR Tchem Apelin receptor 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

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AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

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GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol
INCHI	InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3
InChi Key	IGSZVEPQZANNAB-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)C(C)(C2=NC3=CC=CC=C3S2)O)C
Isomeric SMILES	CC1=CC(=C(C=C1)C(C)(C2=NC3=CC=CC=C3S2)O)C
Alternate CAS	1253901-26-6
PubChem CID	52943938
MeSH Entry Terms	1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol;AC265347
Molecular Weight	283.39

Solubility

Solvent:DMSO, Max Conc. mg/mL: 28.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 28.34, Max Conc. mM: 100

Sensitivity

Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.

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