Ac-FLTD-CMK - 98%, high purity , CAS No.2376255-48-8

Item Number

A414490

Grouped product items
SKU	Size	Availability	Price
A414490-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$279.90
A414490-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$699.90
A414490-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$937.90

Caspase Inhibitors

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Basic Description

Synonyms	N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone
Specifications & Purity	98%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	Information Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively. Targets caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM In vitro A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes. In vivo Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Cell Research(from reference) Cell lines：BMDM cells Concentrations：10 μM Incubation Time：30 mins

Names and Identifiers

IUPAC Name	(3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid
INCHI	InChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1
InChi Key	UCWNTWGHVCSMJP-WPUDHWPRSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C(CC1=CC=CC=C1)NC(=O)C
PubChem CID	155906572
Molecular Weight	569.05

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
B2423466	Certificate of Analysis	Jan 15, 2024	A414490
B2423763	Certificate of Analysis	Jan 15, 2024	A414490
B2423764	Certificate of Analysis	Jan 15, 2024	A414490
B2423765	Certificate of Analysis	Jan 15, 2024	A414490
B2423767	Certificate of Analysis	Jan 15, 2024	A414490
B2423768	Certificate of Analysis	Jan 15, 2024	A414490

Solubility

Solubility (25°C) In vitro DMSO: 100 mg/mL (175.73 mM); Ethanol: 25 mg/mL (43.93 mM); Water: 2 mg/mL (3.51 mM);

Sensitivity

Hygroscopic ;Light sensitive

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Basic Description