Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A129786-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $12.90 | |
A129786-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $31.90 | |
A129786-250mg | 250mg | In stock | $55.90 | |
A129786-1g | 1g | In stock | $182.90 | |
A129786-5g | 5g | In stock | $637.90 | |
A129786-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,229.90 |
Potent, selective, nucleotide analog reverse transcriptase inhibitor
Synonyms | ADEFOVIR DIPIVOXIL|142340-99-6|Hepsera|Preveon|Adefovir pivoxil|bis-POM PMEA|GS-0840|GS 0840|GS 840|GS-840|Adefovir dipivoxil [USAN]|Adefovir di(pivaloyloxymethyl) ester|[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymet |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Powerful and selective nucleotide analogue reverse transcriptase inhibitor. Inhibition of viral DNA synthesis (IC 50=0.2-2.5 μ M. Human liver cancer cell lines transfected with HBV. Display antiviral effects in the body. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target: NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4]. Product Introduction: Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains. Adefovir dipivoxil shows anti-orthopoxvirus activity. |
ALogP | 1.8 |
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Pubchem Sid | 488183410 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183410 |
IUPAC Name | [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate |
INCHI | InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23) |
InChi Key | WOZSCQDILHKSGG-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C |
Isomeric SMILES | CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C |
WGK Germany | 3 |
RTECS | UA2459362 |
PubChem CID | 60871 |
Molecular Weight | 501.47 |
Reaxy-Rn | 7060608 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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A2404078 | Certificate of Analysis | Dec 23, 2023 | A129786 |
A2404079 | Certificate of Analysis | Dec 23, 2023 | A129786 |
A2404080 | Certificate of Analysis | Dec 23, 2023 | A129786 |
A2404081 | Certificate of Analysis | Dec 23, 2023 | A129786 |
A2404082 | Certificate of Analysis | Dec 23, 2023 | A129786 |
A2404096 | Certificate of Analysis | Dec 23, 2023 | A129786 |
C23031360 | Certificate of Analysis | Mar 30, 2023 | A129786 |
C2304155 | Certificate of Analysis | Mar 15, 2023 | A129786 |
C2304156 | Certificate of Analysis | Mar 09, 2023 | A129786 |
G1915047 | Certificate of Analysis | Feb 09, 2023 | A129786 |
Solubility | DMSO : ≥ 100 mg/mL (199.41 mM) H2O : 0.67 mg/mL (1.34 mM; Need ultrasonic) |
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Sensitivity | heat sensitive |
Melt Point(°C) | 101 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | UA2459362 |
Reaxy-Rn | 7060608 |
Merck Index | 151 |