Adriamycinol - 95%（Mixture of Diastereomers）, high purity , CAS No.54193-28-1

Item Number

D344975

• Synonyms: (8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-8-((S)-1,2-dihydroxyethyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione | RP 27706 | RP-27706 | (1S,3S)-3-[(1S)-1,2-dihydroxyethyl]-3,5,12-trihydrox
• Specifications & Purity: ≥95%, Mixture of Diastereomers
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads

Product Description

Doxorubicinol is a cardiotoxic metabolite of Doxorubicin. it can be used as an antineoplastic.

Doxorubicinol belongs to the tetracenequinones class and is the major metabolite of Doxorubicin. It is known to have cardiotoxic and antineoplastic properties. Doxorubicinol is classified as an anthracycline antibiotic, a deoxy hexoside, an aminoglycoside, a phenol, an aromatic ether, a polyol, and a member of p-quinones. It is derived from a tetracene hydride. 

Application：

Adriamycinol can inhibit the diastolic function of isolated papillary muscles ( i.e., increase resting pressure ) ; at a concentration that significantly reduced diastolic function, doxorubicin almost completely eliminated calcium pump activity ; ca2 + -stimulated ATPase activity in sarcoplasmic reticulum of skeletal muscle was inhibited, and Na + / K + -ATPase activity in sarcolemma of canine and rabbit heart preparations was eliminated. The proliferation of PANC-1 cells was inhibited, and the IC50 value was 35.4 μM. The IC50 value of PD PaCa cells was 44.5 μM, and the IC50 value of WD PaCa cells was 49.5 μM.