AF-353 - 98%, high purity , CAS No.865305-30-2, Antagonist of P2X3

Item Number

A412365

• Synonyms: 865305-30-2|AF-353|AF 353|2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-|AF353|5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine|5-(5-IODO-2-ISOPROPYL-4-METHOXYPHENOXY)PYRIMIDINE-2,4-DIAMINE|CHEMBL526307|AF-353(Ro-4)|A
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of P2X3

Product Description

Information

AF-353 AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively.

Targets

hP2X3 (Cell-free assay); rP2X3 (Cell-free assay); hP2X2/3 (Cell-free assay) 8.06(pIC50); 8.05(pIC50); 7.41(pIC50)