AGN 193109 - ≥98%(HPLC), high purity , CAS No.171746-21-7, Antagonist of Retinoic acid receptor-α;Antagonist of Retinoic acid receptor-β;Antagonist of Retinoic acid receptor-γ

Item Number
A286823
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A286823-5mg
5mg
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$149.90
A286823-1mg
1mg
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$59.90
A286823-10mg
10mg
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A286823-25mg
25mg
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A286823-50mg
50mg
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$719.90

High affinity pan-RAR antagonist

Basic Description

Synonyms4-((5,5-Dimethyl-8-(p-tolyl)-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid | AKOS030211125 | (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | GTPL2640 | HY-U00449G | ZC6062V1O9 | 4-[(5,6-d
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsHigh affinity pan-retinoic acid receptor (RAR) antagonist (Kdvalues are 2, 2 and 3 nM at RARα, RARβand RARγ, respectively). Exhibits no significant affinity for retinoic X receptors.AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist th
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of Retinoic acid receptor-α;Antagonist of Retinoic acid receptor-β;Antagonist of Retinoic acid receptor-γ
Product Description

Product description:

AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.


Associated Targets(Human)

RARG Tclin Retinoic acid receptor gamma (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RARB Tclin Retinoic acid receptor beta (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RARA Tclin Retinoic acid receptor alpha (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RARA Tclin Retinoic acid receptor alpha (1324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RARG Tclin Retinoic acid receptor gamma (1154 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RARB Tclin Retinoic acid receptor beta (1232 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-[2-[5,5-dimethyl-8-(4-methylphenyl)-6H-naphthalen-2-yl]ethynyl]benzoic acid
INCHI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
InChi Key NCEQLLNVRRTCKJ-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)C2=CCC(C3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C
Isomeric SMILES CC1=CC=C(C=C1)C2=CCC(C3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C
Alternate CAS 171746-21-7
PubChem CID 177238
MeSH Entry Terms 4-((5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl)ethynyl)benzoic acid;AGN 193109;AGN-193109;AGN193109
Molecular Weight 392.49

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
C2408064Certificate of AnalysisJan 24, 2024 A286823
C2408065Certificate of AnalysisJan 24, 2024 A286823
C2408066Certificate of AnalysisJan 24, 2024 A286823
C2408067Certificate of AnalysisJan 24, 2024 A286823
C2408068Certificate of AnalysisJan 24, 2024 A286823
C2408069Certificate of AnalysisJan 24, 2024 A286823
C2408070Certificate of AnalysisJan 24, 2024 A286823
C2408071Certificate of AnalysisJan 24, 2024 A286823
C2408072Certificate of AnalysisJan 24, 2024 A286823
C2408073Certificate of AnalysisJan 24, 2024 A286823

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 1.96, Max Conc. mM: 5 with gentle warming

Related Documents

Solution Calculators