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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A286823-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $149.90 | |
A286823-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
A286823-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $246.90 | |
A286823-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $496.90 | |
A286823-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $719.90 |
High affinity pan-RAR antagonist
Synonyms | 4-((5,5-Dimethyl-8-(p-tolyl)-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid | AKOS030211125 | (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | GTPL2640 | HY-U00449G | ZC6062V1O9 | 4-[(5,6-d |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | High affinity pan-retinoic acid receptor (RAR) antagonist (Kdvalues are 2, 2 and 3 nM at RARα, RARβand RARγ, respectively). Exhibits no significant affinity for retinoic X receptors.AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist th |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of Retinoic acid receptor-α;Antagonist of Retinoic acid receptor-β;Antagonist of Retinoic acid receptor-γ |
Product Description | Product description: AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. |
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IUPAC Name | 4-[2-[5,5-dimethyl-8-(4-methylphenyl)-6H-naphthalen-2-yl]ethynyl]benzoic acid |
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INCHI | InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30) |
InChi Key | NCEQLLNVRRTCKJ-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC=C(C=C1)C2=CCC(C3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C |
Isomeric SMILES | CC1=CC=C(C=C1)C2=CCC(C3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C |
Alternate CAS | 171746-21-7 |
PubChem CID | 177238 |
MeSH Entry Terms | 4-((5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl)ethynyl)benzoic acid;AGN 193109;AGN-193109;AGN193109 |
Molecular Weight | 392.49 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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C2408064 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408065 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408066 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408067 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408068 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408069 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408070 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408071 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408072 | Certificate of Analysis | Jan 24, 2024 | A286823 |
C2408073 | Certificate of Analysis | Jan 24, 2024 | A286823 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 1.96, Max Conc. mM: 5 with gentle warming |
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