AGN 194078 - 98%, high purity , CAS No.321995-62-4

Item Number

A647818

Grouped product items
SKU	Size	Availability	Price
A647818-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$228.90
A647818-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
A647818-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
A647818-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90

View related series

Basic Description

Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively. In Vitro AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a K d value of 3 nM, while being unable to bind to RARβ and binding only very weakly (K d =5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC 50 value of 112 nM, but only activated\nRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Kd: 4 nM (RARα), EC50: 140 nM (RARα)

Canonical SMILES

O=C(O)C1=C(F)C=C(NC(C2=C(O)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F

Molecular Weight

403.42

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description