| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A655183-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $528.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively. In Vitro AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a K d value of 3 nM, while being unable to bind to RARβ and binding only very weakly (K d =5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC 50 value of 112 nM, but only activated\nRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Kd: 4 nM (RARα), EC50: 140 nM (RARα) |
| Canonical SMILES | O=C(O)C1=C(F)C=C(NC(C2=C(O)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F |
|---|---|
| Molecular Weight | 403.42 |
Enter Lot Number to search for COA:
