AH 6809 - 97%, high purity , CAS No.33458-93-4, Antagonist of DP 1 receptor;Antagonist of EP 1 receptor;Antagonist of EP 2 receptor;Antagonist of EP 3 receptor
AH 6809 - 97%, high purity , CAS No.33458-93-4, Antagonist of DP 1 receptor;Antagonist of EP 1 receptor;Antagonist of EP 2 receptor;Antagonist of EP 3 receptor
EP 1 and EP 2 antagonist (K i values are 333 and 350 nM, respectively). Specific DP 2 receptor antagonist (pA 2 = 4.45).
AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.
DP/EP prostanoid receptor antagonist;
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of DP 1 receptor;Antagonist of EP 1 receptor;Antagonist of EP 2 receptor;Antagonist of EP 3 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Application
AH6809 has been used:
as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)
I2207230