AHR antagonist 5 - 10mM in DMSO, high purity , CAS No.2247953-39-3(DMSO)

  • 10mM in DMSO
Item Number
A655964
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SKUSizeAvailabilityPrice Qty
A655964-1ml
1ml
Available within 8-12 weeks(?)
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$726.90

Basic Description

Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsAHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC 50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC 50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.

In Vivo

Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Balb/c Mice (Mouse Colorectal Cancer Model CT26) Dosage: 10 mg/kg (combination with anti-PD-1) Administration: P.o.; every day for 3 weeks Result: Significantly inhibited tumor growth inhibition.

Names and Identifiers

Canonical SMILES CC(C1=C2N(N=C1)C(N[C@H]3CC(C4=CC=CC=C4N5)=C5CC3)=NC(C6=CN=CC(F)=C6)=N2)C.Cl.Cl.Cl
Molecular Weight 550.89

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