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AJ-76 HCL - ≥98%, high purity , CAS No.85378-82-1, Antagonist of D 3 receptor
a selective antagonist of dopamine autoreceptors
Basic Description Synonyms 85379-09-5|AJ 76|5-methoxy-1-methyl-2-(n-propylamino)tetralin|AJ-76|(1S,2R)-5-methoxy-1-methyl-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine|(+)-AJ76|CHEMBL27441|(+)-AJ 76|CHEBI:64117|(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin|cis-(+)-5-methoxy-1- Specifications & Purity ≥98% Storage Temp Store at 2-8°C Shipped In Wet ice Action Type ANTAGONIST Mechanism of action Antagonist of D 3 receptor Product Description AJ-76 HCL is a selective antagonist of dopamine autoreceptors, which displays a reduction in ventral firing rates of dopaminergic neurons. Studies indicate that AJ-76 HCL increases dopamine synthesis in the nigrostriatal system in neurons with partial lesions. It is known that the effects of AJ-76 HCL displays similar effects on dopamine receptors as cocaine. Based on these properties this compound is essential in studying the effects of cocaine on dopamine release from neurons.
Names and Identifiers IUPAC Name (1S,2R)-5-methoxy-1-methyl-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine;hydrochloride INCHI InChI=1S/C15H23NO.ClH/c1-4-10-16-14-9-8-13-12(11(14)2)6-5-7-15(13)17-3;/h5-7,11,14,16H,4,8-10H2,1-3H3;1H/t11-,14+;/m0./s1 InChi Key KIRYNZFMOLYYQB-YECZQDJWSA-N Canonical SMILES CCCNC1CCC2=C(C1C)C=CC=C2OC.Cl Isomeric SMILES CCCN[C@@H]1CCC2=C([C@@H]1C)C=CC=C2OC.Cl PubChem CID 13755572 Molecular Weight 269.81
Chemical and Physical Properties Solubility Soluble in 50% aq. ethanol (20 mg/ml) Sensitivity Moisture sensitive
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