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Enzymes
3.5.1.- Histone deacetylases (HDACs)
AKK(thioAc)LM²¹ , CAS No.A607473, Inhibitor of sirtuin 6

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AKK(thioAc)LM²¹ , CAS No.A607473, Inhibitor of sirtuin 6

Moligand™

PubChem CID: 44572818

Item Number

A607473

Grouped product items
SKU	Size	Availability	Price	Qty
A607473-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607473-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,900.90

View related series

sirtuin 6 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of sirtuin 6

Associated Targets

SIRT2 Tchem NAD-dependent protein deacetylase sirtuin-2 0 Activities

Discover Target: SIRT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT6 Tchem NAD-dependent protein deacetylase sirtuin-6 1 Activities

Discover Target: SIRT6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT1 Tchem NAD-dependent protein deacetylase sirtuin-1 0 Activities

Discover Target: SIRT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-aminopropanoyl]amino]hexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
INCHI	InChI=1S/C28H53N7O6S2/c1-17(2)16-23(27(39)34-22(28(40)41)12-15-43-5)35-26(38)21(11-7-9-14-31-19(4)42)33-25(37)20(10-6-8-13-29)32-24(36)18(3)30/h17-18,20-23H,6-16,29-30H2,1-5H3,(H,31,42)(H,32,36)(H,33,37)(H,34,39)(H,35,38)(H,40,41)/t18-,20-,21-,22-,23-/m0/s1
InChi Key	IIESJRORKKINMK-SVXFZJLFSA-N
Canonical SMILES	NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCSC)CC(C)C)CCCCNC(=S)C)NC(=O)[C@@H](N)C
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=S)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)N
PubChem CID	44572818

Database links

ChEMBL Ligand	CHEMBL504711
PubChem CID	44572818

Certificates

Certificate of Analysis(COA)

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References

1. Kokkonen P, Rahnasto-Rilla M, Kiviranta PH, Huhtiniemi T, Laitinen T, Poso A, Jarho E, Lahtela-Kakkonen M. (2012) Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.. ACS Med Chem Lett, 3 (12): (969-74). [PMID:24900419]

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