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AKT1 Mouse mAb - Primary antibody, for WB,Flow,ELISA,IF,ICC various applications, from Human, generated in Mouse, specific to AKT1, IgG1

Features and benefits
  • Specifications & Purity: ExactAb™, Validated, Carrier Free, 1.0mg/mL
  • Short Overview:

    mAb (1F7E10); Mouse anti Human AKT1 Antibody; WB, ICC, IF, Flow, ELISA; Unconjugated

  • Application: WB,Flow,ELISA,IF,ICC
  • Species reactivity(Reacts with): Human,Monkey,Mouse,Rat
  • Isotype: IgG1
Item Number
Ab087937
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Ab087937-10μl (Trial Size)
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10μl
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$66.90
Ab087937-50μl
50μl
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$198.90
Ab087937-100μl
100μl
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$321.90
Ab087937-1ml
1ml
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Production requires sourcing of materials. We appreciate your patience and understanding.
$2,937.90
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mAb (1F7E10); Mouse anti Human AKT1 Antibody; WB, ICC, IF, Flow, ELISA; Unconjugated

View related series
Accession#:P31749 AKT1 Gene ID:207

Basic Description

Product NameAKT1 Mouse mAb - Primary antibody, for WB,Flow,ELISA,IF,ICC various applications, from Human, generated in Mouse, specific to AKT1, IgG1
SynonymsAKT 1 antibody; AKT antibody; AKT1 antibody; AKT1_HUMAN antibody; C AKT antibody; cAKT antibody; MGC99656 antibody; PKB alpha antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-onc
Specifications & PurityExactAb™, Validated, Carrier Free, 1.0mg/mL
Host SpeciesMouse
Host speciesMouse
SpecificityAKT1
ApplicationWB,Flow,ELISA,IF,ICC
ImmunogenPurified recombinant fragment of human AKT1 (AA: 1-150) expressed in E. Coli.
Positive ControlWB: Recombinant human AKT1 (aa 1-150); MCF7, NIH/3T3, COS-7 and C6 cell lysates; AKT1 (aa 1-150)-hIgGFc transfected HEK-293 whole cell lysate. ICC/IF: HepG2 cells. Flow: HeLa cells.
ConjugateUnconjugated
GradeCarrier Free, ExactAb™, Validated

Product Properties

Antibody TypePrimary antibody
ClonalityMonoclonal antibodies
IsotypeIgG1
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein G purified
SourceAscitic fluid
FormLiquid
Concentration1.0mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InDry ice
Stability And StorageShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Associated Targets

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationNotes
WB

1/500-1/2000

IF/ICC

1/200-1/1000

Flow

1/200-1/400

ELISA

1/10000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0700655Certificate of AnalysisJul 21, 2023 Ab087937
ZJ23F0700656Certificate of AnalysisJul 21, 2023 Ab087937

Safety and Hazards(GHS)

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Immunohistochemistry staining with samples in paraffin (IHC-P)
Categories: Protocols
Tags:
Monoclonal antibody Paraffin Section Immunohistochemistry/IHC

References

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220. Kane, Susan S and 6 more authors..  (2002)  A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain..  The Journal of biological chemistry,    (21):   [PMID:11994271]
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226. Heilig, Roland R and 98 more authors..  (2003)  The DNA sequence and analysis of human chromosome 14..  Nature,    (6):   [PMID:12508121]
227. He, Zhiwei Z and 5 more authors..  (2003)  Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1..  The Journal of biological chemistry,    (21):   [PMID:12529330]
228. Lennartsson, Johan J, Wernstedt, Christer C, Engström, Ulla U, Hellman, Ulf U and Rönnstrand, Lars L..  (2003)  Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk..  Experimental cell research,    (1):   [PMID:12878163]
229. Remy, Ingrid I and Michnick, Stephen W SW..  (2004)  Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt..  Molecular and cellular biology,      [PMID:14749367]
230. Ahn, Jee-Yin JY and 5 more authors..  (2004)  PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion..  The Journal of biological chemistry,    (16):   [PMID:14761976]
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233. Rönnstrand, L L..  (2004)  Signal transduction via the stem cell factor receptor/c-Kit..  Cellular and molecular life sciences : CMLS,      [PMID:15526160]
234. Ivanov, Vladimir N VN and Hei, Tom K TK..  (2005)  Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway..  Oncogene,    (20):   [PMID:15580309]
235. Cartlidge, Robert A RA and 5 more authors..  (2005)  The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells..  The EMBO journal,    (4):   [PMID:15861136]
236. Enomoto, Atsushi A and 9 more authors..  (2005)  Akt/PKB regulates actin organization and cell motility via Girdin/APE..  Developmental cell,      [PMID:16139227]
237. Tsou, Tsui-Chun TC and 5 more authors..  (2005)  Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase..  Toxicology and applied pharmacology,    (1):   [PMID:16239170]
238. Brandts, Christian H CH and 11 more authors..  (2005)  Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation..  Cancer research,    (1):   [PMID:16266983]
239. Srinivas, Harish H and 8 more authors..  (2006)  Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha..  The Biochemical journal,    (1):   [PMID:16417524]
240. Zhang, Xiaoling X and 6 more authors..  (2006)  Kinetic mechanism of AKT/PKB enzyme family..  The Journal of biological chemistry,    (19):   [PMID:16540465]
241. Fritzius, Thorsten T and 10 more authors..  (2006)  A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda..  The Biochemical journal,    (1):   [PMID:16792529]
242. Héron-Milhavet, Lisa L and 7 more authors..  (2006)  Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding..  Molecular and cellular biology,      [PMID:16982699]
243. Schick, Volker V and 9 more authors..  (2006)  Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias..  Acta neuropathologica,      [PMID:17013611]
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247. Cinar, Bekir B and 8 more authors..  (2007)  The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1..  The EMBO journal,    (31):   [PMID:17932490]
248. Shome, Debraj D and 7 more authors..  (2008)  Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine..  Ophthalmology,      [PMID:18201764]
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251. Landgraf, Kyle E KE, Pilling, Carissa C and Falke, Joseph J JJ..  (2008)  Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain..  Biochemistry,    (25):   [PMID:18954143]
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253. Yang, Wei-Lei WL and 10 more authors..  (2009)  The E3 ligase TRAF6 regulates Akt ubiquitination and activation..  Science (New York, N.Y.),    (28):   [PMID:19713527]
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256. Romano, David D and 5 more authors..  (2010)  Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt..  Cancer research,    (1):   [PMID:20086174]
257. Kim, Donghwa D and 5 more authors..  (2010)  Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway..  PloS one,    (9):   [PMID:20231902]
258. Mahajan, Kiran K and 15 more authors..  (2010)  Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation..  PloS one,    (19):   [PMID:20333297]
259. Bobkova, Ekaterina V EV and 9 more authors..  (2010)  Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening..  The Journal of biological chemistry,    (11):   [PMID:20385558]
260. Chin, Y Rebecca YR and Toker, Alex A..  (2010)  The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration..  Molecular cell,    (14):   [PMID:20471940]
261. Nam, Seon Young SY and 8 more authors..  (2010)  Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation..  The Journal of biological chemistry,    (8):   [PMID:20682768]
262. Wu, Wen-I WI and 5 more authors..  (2010)  Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition..  PloS one,    (23):   [PMID:20886116]
263. Kunoh, Tatsuki T and 13 more authors..  (2010)  A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells..  Molecular cancer therapeutics,      [PMID:20978158]
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267. Xie, Xiaoduo X and 7 more authors..  (2011)  IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation..  Proceedings of the National Academy of Sciences of the United States of America,    (19):   [PMID:21464307]
268. Hers, Ingeborg I, Vincent, Emma E EE and Tavaré, Jeremy M JM..  (2011)  Akt signalling in health and disease..  Cellular signalling,      [PMID:21620960]
269. Sundaresan, Nagalingam R NR and 9 more authors..  (2011)  The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy..  Science signaling,    (19):   [PMID:21775285]
270. Lindhurst, Marjorie J MJ and 39 more authors..  (2011)  A mosaic activating mutation in AKT1 associated with the Proteus syndrome..  The New England journal of medicine,    (18):   [PMID:21793738]
271. Bae, Seunghee S and 16 more authors..  (2012)  Akt is negatively regulated by the MULAN E3 ligase..  Cell research,      [PMID:22410793]
272. Wang, Shuai and 13 more authors..  (2012)  Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling..  PloS one,      [PMID:22629392]
273. Sen, Tanusree T and 7 more authors..  (2012)  OGDHL is a modifier of AKT-dependent signaling and NF-κB function..  PloS one,      [PMID:23152800]
274. Orloff, Mohammed S MS and 6 more authors..  (2013)  Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes..  American journal of human genetics,    (10):   [PMID:23246288]
275. Peng, Bo B, Gu, Yixue Y, Xiong, Yan Y, Zheng, Guopei G and He, Zhimin Z..  (2012)  Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma..  PloS one,      [PMID:23251525]
276. Yao, Yixin Y and 13 more authors..  (2013)  BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation..  Science signaling,    (8):   [PMID:23300339]
277. Rokudai, Susumu S and 5 more authors..  (2013)  MOZ increases p53 acetylation and premature senescence through its complex formation with PML..  Proceedings of the National Academy of Sciences of the United States of America,    (5):   [PMID:23431171]
278. Cipriano, Rocky R and 5 more authors..  (2013)  FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies..  Oncotarget,      [PMID:23676467]
279. Zhuo, De-Xiang DX and 7 more authors..  (2013)  CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site..  PloS one,      [PMID:23799035]
280. Singel, Stina M SM and 13 more authors..  (2014)  KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer..  Neoplasia (New York, N.Y.),      [PMID:24784001]
281. Seo, Gil Ju and 9 more authors..  (2015)  Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway..  Cell reports,    (13):   [PMID:26440888]
282. Yu, Jia J and 9 more authors..  (2017)  Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7..  Cell reports,    (31):   [PMID:28147277]

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