| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A638732-5.2mg | 5.2mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $681.90 |
| Storage Temp | Store at -20°C |
|---|---|
| Shipped In | Ice chest + Ice pads |
| Product Description | Product introduction： The Click-iT™ GalNAz metabolic glycoprotein labeling reagent provides the first part of a simple and robust two-step technique to identify and characterize cell surface O-linked glycoproteins. In step one, cultured cells are incubated with the azide-modified galactosamine (GalNAz). The azido-sugar is metabolically incorporated into cell surface O-linked glycoproteins through the permissive nature of the oligosaccharide biosynthesis pathway. In step two, via the chemoselective ligation or click reaction between an azide and an alkyne, the azido-labeled glycoproteins can then be detected with a Click-iT™ Glycoprotein Detection Kit for gels (TAMRA or Dapoxyl™ alkyne) or Western blots (biotin alkyne). These Click-iT™ products are compatible with LC-MS⁄MS and Multiplexed Proteomics™ technologies for in-depth analyses of the glycoproteome. • Green Features:Less hazardous • Labeling Target:Proteins(Glycoproteins) |
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| 1. Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H,. () Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB.. J Virol, [PMID:19812165] |
| 2. Laughlin ST, Agard NJ, Baskin JM, Carrico IS, Chang PV, Ganguli AS, Hangauer MJ, Lo A, Prescher JA, Bertozzi CR,. () Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics.. Methods Enzymol, [PMID:17116478] |
| 3. Liu K, Yang PY, Na Z, Yao SQ,. () Dynamic monitoring of newly synthesized proteomes: up-regulation of myristoylated protein kinase A during butyric acid induced apoptosis.. Angew Chem Int Ed Engl, [PMID:21678537] |
| 4. Schwetz TA, Norring SA, Ednie AR, Bennett ES,. () Sialic Acids Attached to O-Glycans Modulate Voltage-gated Potassium Channel Gating.. J Biol Chem, [PMID:21115483] |
| 5. Ludwig T, Theissen SM, Morton MJ, Caplan MJ,. () The cytoplasmic tail dileucine motif LL572 determines the glycosylation pattern of membrane-type 1 matrix metalloproteinase.. J Biol Chem, [PMID:18955496] |
