Alizarin violet - >85.0%(HPLC), high purity , CAS No.2103-64-2

Item Number

A116396

• Synonyms: Gallein|2103-64-2|Alizarin violet|Pyrogallolphthalein|Mordant violet 25|3',4',5',6'-Tetrahydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one|C.I. Mordant Violet 25|Pyrogallol phthalein|4,5-Dihydroxyfluorescein|C.I. 45445|3',4',5',6'-Tetrahydroxyfluoran|Spi
• Specifications & Purity: ≥85%(HPLC)
• Biochemical and Physiological Mechanisms: Inhibitor of G proteinβγsubunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Note: 5g、25g卖完停产，不再备货

Product Description

Gallein is a cell-permeable xanthene compound that binds to Gβγ with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities. Gallein is reported to exhibit prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model. Gallein is an inhibitor of G β and G γ
An inhibitor of Gβγ-dependent cellular activities which binds to Gβγ with high affinity