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alpha-Melanocyte Stimulating Hormone amide - ≥97% (HPLC), high purity , CAS No.171869-93-5

2 Citations

≥97%(HPLC)

CAS#: 171869-93-5
Formula: C₇₉H₁₁₀F₃N₂₁O₂₁S
Molecular Weight: 1778.9
MDL number: MFCD00133062
PubChem CID: 145710782

Item Number

M118985

Grouped product items
SKU	Size	Availability	Price
M118985-5mg	5mg	In stock	$99.90
M118985-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$339.90
M118985-100mg	100mg	In stock	$959.90

Endogenous melanocortin receptor agonist

View related series

GPCR/G Protein Melanocortin Receptor Neuronal Signaling

Basic Description

Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Pituitary hormone which causes darkening skin pigmentation from amphibians to humans. In mammals, it can also have behavioral effects on learning, attention, and memory. Hormone that stimulates melanogenesis; facilitates learning and memory; affects infla
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Names and Identifiers

IUPAC Name	(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;2,2,2-trifluoroacetic acid
INCHI	InChI=1S/C77H109N21O19S.C2HF3O2/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101;3-2(4,5)1(6)7/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83);(H,6,7)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-;/m0./s1
InChi Key	FEOXCJFWEWYJIH-VLZMNQITSA-N
Canonical SMILES	CC(C)C(C(=O)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C.C(=O)(C(F)(F)F)O
Alternate CAS	581-05-5
PubChem CID	145710782
Molecular Weight	1778.9

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
A2404705	Certificate of Analysis	Dec 12, 2023	M118985
A2404706	Certificate of Analysis	Dec 12, 2023	M118985
A2404707	Certificate of Analysis	Dec 12, 2023	M118985
A1916135	Certificate of Analysis	Nov 14, 2022	M118985
A1916134	Certificate of Analysis	Nov 14, 2022	M118985
D2320085	Certificate of Analysis	Nov 11, 2021	M118985

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng. (2023) Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway. Frontiers in Pharmacology, 14 [PMID:36814484] [10.3389/fphar.2023.1081030]
2. Lv Jinpeng, Yang Ying, Jia Bingyi, Li Siqi, Zhang Ximei, Gao Rongyin. (2021) The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation. Frontiers in Pharmacology, 12 (3389). [PMID:34887767] [10.3389/fphar.2021.783730]

References

1. Löw K et al.. (2020) A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs.. FEBS Lett, 594 (17): (2840-2866). [PMID:32506501]
2. Brami-Cherrier K et al.. (2022) Botulinum Neurotoxin Type A Directly Affects Sebocytes and Modulates Oleic Acid-Induced Lipogenesis.. Toxins (Basel), 14 (10): [PMID:36287976]
3. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng. (2023) Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway. Frontiers in Pharmacology, 14 [PMID:36814484] [10.3389/fphar.2023.1081030]
4. Lv Jinpeng, Yang Ying, Jia Bingyi, Li Siqi, Zhang Ximei, Gao Rongyin. (2021) The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation. Frontiers in Pharmacology, 12 (3389). [PMID:34887767] [10.3389/fphar.2021.783730]

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