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Alvelestat - ≥98%, high purity , Leukocyte elastase inhibitor, CAS No.848141-11-7, Leukocyte elastase inhibitor

Specifications & Purity:  ≥98%
Item Number
A127407
Grouped product items
SKUSizeAvailabilityPrice Qty
A127407-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$75.90
A127407-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$107.90
A127407-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$243.90
A127407-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$325.90
A127407-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$489.90

Basic Description

Synonyms848141-11-7|Alvelestat|Alvelestat (AZD9668)|Alvelestat [INN]|Alvelestat; AZD 9668|avelestat-azd9668|AZD 9668|AZD-9668|AZD9668|AZD9668;AZD-9668;AZD 9668|Alvelestat (AZD9688)|MPH966|6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)me
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionLeukocyte elastase inhibitor

Product Properties

ALogP2.5

Associated Targets

ELANE Tclin Neutrophil elastase 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
INCHI InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)
InChi Key QNQZWEGMKJBHEM-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C
Isomeric SMILES CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C
PubChem CID 46861623
Molecular Weight 545.53

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
D1517081Certificate of AnalysisDec 12, 2022 A127407

Chemical and Physical Properties

Solubility25°C: DMSO

Related Documents

References

1. Stevens T, Ekholm K, Gränse M, Lindahl M, Kozma V, Jungar C, Ottosson T, Falk-Håkansson H, Churg A, Wright JL et al..  (2011)  AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase..  J Pharmacol Exp Ther,  339  (1): (313-20).  [PMID:21791628]

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